Estimation of the Infarct Size on Occlusion of the Middle Cerebral Artery in Primates
1105-1108
Correspondence
Dr. Somesh M.S. Assistant Professor, Department of Anatomy, Srinivas Institute of Medical Sciences & Research Centre (SIMS &RC), Mukka, Mangalore - 574146, India. Phone: 91 – 0824 – 2425966, 09686924032 E-mail: drsomeshms@gmail.com
Introduction: The model of single artery occlusion in subhuman primates was studied, to verify whether there is any correlation between micro-circulatory perfusion impairment and area of in¬farction after occlusion of middle cerebral artery and to find out whether there is any definite “reperfusion window’ which could be used effectively to prevent or reduce the area of infarction. Materials and Methods: For the present study 24 healthy adult monkeys of either sex were procured and the Middle cerebral artery (MCA) was occluded and reperfused for given set of time periods and the infarction size of the brain was determined. Results: The percentage of the infarction size after occluding the blood vessel increased considerably, as the time interval prolonged. After the reperfusion of the arteries for shorter inter¬vals like 30 min, 4 hours and 12 hours, there was a significant decrease in the infarct size, whereas there was no effect on the infarct size after 12 hours. Conclusion: In the regions of focal cerebral ischaemia, the ad¬verse effect of focal ischemia may be minimized if, in the acute phase, functional microcirculation is increased by some thera¬peutic intervention aimed at augmenting blood flow through the ischemic region.