Evaluation of Pre-Malignant and Malignant Lesions in Cervico Vaginal (Pap ) Smears by Nuclear Morphometry
FC16-FC19
Correspondence
Dr. Aparna Narasimha,
No. 22, “Moyenvilla”, Moyenville Road, Langford Town, Bangalore - 25, India.
Phone : 9632140850, E-mai : Sonrichie14@gmail.com
Background: Cervical cancer is the second most common cancer occurring among women worldwide, with almost half a million new cases each year. Normal cells gradually transform to form cancer cells through several stages. So, the changes occurring during the transformational stages need to be assessed.
Aim: Our aim was to study various nuclear parameters useful in evaluating pre-malignant and malignant cervico-vaginal pap smears. Materials and Methods: Bethesda System was used to categorize cervical pap smears into premalignant and malignant lesions. Nuclear parameters were calculated using J 1.44C morphometric software. Several nuclear size parameters were analysed.
Results: The nuclear area, perimeter, diameter were found to be statistically significant (p<0.05) parameters in differentiating premalignant from malignant cervical smears.
Conclusion: Nuclear morphometry was thus a useful objective tool in differentiating premalignant from malignant cervical smears.