Comparison of Effect of Lavandula officinalis and Venlafaxine in Treating Depression: A Double Blind Clinical Trial KC01-KC04
Dr. Hourivash Ghaderi,
Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Introduction: Major depressive disorder is a chronic disease which may be associated with other mental illnesses. Lavandula officinalis and venlafaxine, herbal and chemical drugs respectively, are used to treat depression. Despite pharmacotherapy, major depressive disorder has a complicated pattern of resistance and recurrence.
Aim: The aim of this study was to determine the effect of L. officinalis and venlafaxine in treating depression.
Materials and Methods: For this study, 120 patients referred to the psychiatry clinic of the Shahrekord University of Medical Sciences, Shahrekord, Iran, were randomly selected. The participants were randomly assigned to three groups: venlafaxine (Control Group), venlafaxine + L. officinalis (L. officinalis Group), and venlafaxine + placebo (Placebo Group). All the patients underwent treatment for six weeks. Depression test was administered to the three groups at different time intervals-before the treatment, four weeks after the treatment and at completion of the treatment. The data were analysed by SPSS version17.0.
Results: Depression scores of all the groups decreased over time (p=0.001). The depression scores were significantly different between the control and L. officinalis groups (p=0.004), and the control and placebo groups (p=0.002), but were not significantly different between the L. officinalis and placebo groups (p=0.95).
Conclusion: Adding L. officinalis or a placebo is equally effective in decreasing mean depression score, and venlafaxine obviously decreased this score.