Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Table of Contents - Year : 2017 | Month : July | Volume : 11 | Issue : 7 | Page : LC01 - LC03

Evaluation of the Relationship between Serum 25-Hydroxy Vitamin D and Hypertension in Hamadan, Iran-A Case Control Study LC01-LC03

Behshad Naghshtabrizi, Shiva Borzouei, Pedram Bigvand, Mohamadali Seifrabiei

Correspondence
Dr. Mohamad Ali Seifrabiei,
Associate Professor, Department of Community Medicine, Hamadan Medical School,
Hamadan University of Medical Sciences, Hamadan-6517838736, Iran.

Introduction: Hypertension or high blood pressure is one of the main reasons of fatality in the world. The role of vitamin D in developing hypertension has not been proved yet. Some studies have shown positive correlation between low serum vitamin D level and hypertension. Due to this fact, recognising hypertension risk factors such as potential impact of low serum vitamin D level seems to be required.

Aim: This study was conducted to evaluate potential impact of serum vitamin D level on hypertension.

Materials and Methods: This case-control study had 188 subjects including 55 cases suffering from hypertension and 133 controls with normal blood pressure in Hamadan, Iran. After taking the medical history and physical examination, 5 cc of their blood was taken to measure their serum 25-Hydroxyvitamin D [25(OH)D] level through ELISA test. Data analysis was done by version 16.0 of SPSS software and used independent sample t-test and Chi-square test for related comparisons.

Results: Mean and standard deviation of serum 25(OH)D level in patients suffering from hypertension was 13.109.7 ng/ml and in control group was 20.8710.34 ng/ml. This variance was statistically significant (p<0.001). Mean serum 25(OH)D level in both case and control groups was measured after gender and age stratification. Mean serum 25(OH)D level in cases and controls was 13.1211.4 ng/ml and 21.3811.47 ng/ml in males (p=0.016) and 13.109.91 ng/ml and 19.1910.55 ng/ml (p=0.004) in females, respectively. Mean serum 25(OH)D level in under 50-year-old was 10.828.73 ng/ml and 20.0711.17 ng/ml in cases and controls respectively (p<0.001). In over 50-year-old, there was no significant relationship between mean serum 25(OH)D and blood pressure levels (p>0.05).

Conclusion: According to this study, reverse relationship between serum 25(OH)D and blood pressure levels was seen.