Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Table of Contents - Year : 2017 | Month : July | Volume : 11 | Issue : 7 | Page : ZD10 - ZD12

Denovo High Grade Salivary Duct Carcinoma: A Case Report and Review of Literature ZD10-ZD12

Heena Zainab, Ameena Sultana, Pramod Jahagirdar

Correspondence
Dr. Heena Zainab
Professor and Head, Department of Oral and Maxillofacial Pathology and Microbiology,
Al Badar Rural Dental College and Hospital, Kalaburgi-585102, Karnataka, India.
E-mail: hinazainab1@yahoo.co.in

Salivary Duct Carcinoma (SDC) is a distinctive and clinically aggressive adenocarcinoma of salivary origin. It arises from the ductal epithelium, predominantly occurring in the major salivary glands, especially the parotid gland. Here, we report a case of an extensive salivary gland pathology involving the right side of face, possibly arising from the parotid gland in a 25-year-old male patient. On routine histopathology, the tumour mass revealed a papillary pattern of neoplastic ductal epithelial cells showing comedo-like-central necrosis. Immunohistochemical staining showed tumour cells in the infiltrative component to be diffusely immunopositive for cytokeratin-7 and Her-2, confirming the diagnosis of SDC. This paper presents a case report on salivary duct carcinoma and highlights a review on histological variants of salivary duct carcinoma.