Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Table of Contents - Year : 2018 | Month : July | Volume : 12 | Issue : 7 | Page : SC01 - SC06

A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern India SC01-SC06

Padmanabhan P Athira, Ozhiparambil A Jagan, Padma Umadevi, Komaravolu Pragnatha, P Menon Veena

Correspondence
Dr. P Menon Veena,
Professor, Department of Clinical Virology, Amrita Institute of Medical Sciences, AIMS Ponekkara, Kochi-682041, Kerala, India.
E-mail: vpmenon26@gmail.com

Introduction: Dengue is an important arthropod-borne viral infection in humans and is the second most important reemerging tropical disease. Children are particularly at risk of developing severe dengue and clinically identifying such cases are often a challenge.

Aim: To characterise the clinical and laboratory risk factors of dengue fever and its severity in children.

Materials and Methods: Retrospective evaluation of demographics, clinical, laboratory findings and outcome of suspected dengue fever in children admitted to the hospital between Jan 2015 - Feb 2017 was performed to identify risk factors of dengue fever and its severity.

Results: During the study period, a total of 211 children were clinically suspected on the admission as dengue fever, 34 of these were serologically confirmed dengue positive. A 74% (27/34) of these were primary dengue infections. The mean age of the dengue cohort was 7.6 years (s.d. 4.8) with 59% (20/34) being boys. Based on 2009 WHO clinical criteria, 16 were identified as Dengue with warning Signs (DS), 7 as Dengue Without warning Signs (DWS) while 11 were identified as Severe Dengue (SD). Some of the frequently observed clinical features were fever (31/34), headache (5/34), thrombocytopenia (9/34), leukopenia (4/34) and rash (5/34). The mean WBC in children with severe dengue was 7.9 % (s.d.5.0) with elevated monocytes 12.2 % (s.d.3.5) compared to 11.3% (s.d.5.8) and 6.6% (s.d.2.0) in children with DS and DWS respectively. Transaminitis was more frequently observed in severe dengue.

Conclusion: Clinical and laboratory parameters of acute febrile illness in children can act as early prognosticators of dengue fever and its severity.