Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : April | Volume : 11 | Issue : 4 | Page : CC01 - CC03

Systemic and Local Effects of Warm Oxygen Exposure to the Lower Extremities in Healthy Volunteers

vidya sunil joshi, sunil subhash joshi, Maruthy

1. Associate Professor, Department of Physiology, Vydehi Institute of Medical Sciences and Research, Bengaluru, Karnataka, India. 2. Associate Professor, Department of Vascular Surgery, St Johns Medical College Hospital, Sarjapur Road, Bengaluru, Karnataka, India. 3. Professor, Department of Physiology, Narayana Medical College, Nellore, Andhra Pradesh, India.

Correspondence Address :
Dr. Vidya Sunil Joshi,
Associate Professor, Department of Physiology, VIMS&RC, #82 EPIP Area, Nallurahalli, Whitefield,
Bengaluru-560066, Karnataka, India


Introduction: Warmth to the extremity is known to improve the cutaneous blood flow and tissue perfusion. Oxygen is essential for healing of chronic wounds. Topical oxygen therapy has become standard therapy in management of lower extremity wounds. A combination of local heat and oxygen is likely to be beneficial in many clinical scenarios of non-healing wounds without any systemic effects.

Aim: To evaluate the local and systemic effects of the exposure of extremity to warm oxygen in healthy volunteers.

Materials and Methods: Thirty one volunteers were included in the study. The index foot was exposed to oxygen 7l/min, 93%-95% concentration at temperature of 43oC for 90 minutes with the device. The following parameters such as basal and periprocedural blood pressure, body temperature, heart rate, 24 lead ECG, temperatures at foot and plethysmographic waveforms from the index foot were measured. A NRS-11 questionnaire was asked to the patient to rate his or her pain from 0 to 10 and documented by health care worker at the end of the session.

Results: The skin temperature of index foot reached to 34oC from 32.9oC, (p=0.011). The average pulse amplitude changed from 39.8 mV to 79.8 mV over the duration of the experiment (p< 0.001). Overall heart rate and core body temperature decreased and not much change in blood pressure.

Conclusion: The result of the study can be extrapolated to the healing of chronic non healing wounds using warm oxygen therapy. Further studies are required on patient population to prove benefits in clinical settings.


Blood flow, Healing, Heat, Oxygen, Plethysmography, Therapy, Wound

How to cite this article :

vidya sunil joshi, sunil subhash joshi, Maruthy. SYSTEMIC AND LOCAL EFFECTS OF WARM OXYGEN EXPOSURE TO THE LOWER EXTREMITIES IN HEALTHY VOLUNTEERS. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 May 27 ]; 11:CC01-CC03. Available from

DOI and Others

DOI: 10.7860/JCDR/2017/23603.9679

Date of Submission: Aug 25, 2016
Date of Peer Review: Sep 20, 2016
Date of Acceptance: Dec 23, 2016
Date of Publishing: Apr 01, 2017


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