Immunohistochemical Study of MUC1, MUC2 and MUC5AC Expression in Primary Breast CarcinomaCorrespondence Address :
Dr. Siddhi Gaurish Sinai Khandeparkar,
E-517, The Island, Wakad, Pune-411057, Maharashtra, India.
Introduction: Breast Cancer (BC) is the second most common cancer among women in India and accounts for 7% of global burden of BC and one-fifth of all Cancers (CA) among women in India.
Aim: This study was conducted for studying the expression of MUC1, MUC2 and MUC5AC in breast carcinoma.
Materials and Methods: Fifty cases of primary breast carcinoma diagnosed between years 2013 to 2015 were included in the study. Manual tissue array technique was applied for cases subjected to Immunohistochemistry (IHC). An analysis of the expression of IHC markers (MUC1, MUC2, MUC5AC, ER, PR and HER2/neu) was attempted. Results were subjected to statistical analysis. They were considered to be significant when the p-value was less than 0.05.
Results: The positivity for MUC1, MUC2 and MUC5AC in BC was 58%, 8% and 6% and for ER, PR and HER2 was 48%, 36% and 64% respectively. There was a significant correlation between MUC1 expression and ER and PR positivity. There was a significant correlation between MUC2 expression and ER positivity. No significant association was observed between MUC2 and PR expression, MUC5AC expression and ER and PR positivity. There was statistically significant correlation between negative MUC2 and MUC5AC expression and histopathological grade. It was noted that MUC2 and MUC5AC negative tumours were associated with higher tumour stage though not statistically significant. It was noted that MUC5AC negative tumours showed higher frequency of lymphovascular invasion though not statistically significant.
Conclusion: Our experience with the present study highlights the role of mucins in the development and progression of BC.
Immunoreactivity, Modified radical mastectomy, Mucin expression
Daxesh Shivabhai Patel, Siddhi Gaurish Sinai Khandeparkar, Avinash R Joshi, Maithili Mandar Kulkarni,
Bhagyashree Dhande, Pranoti Lengare, et al.. IMMUNOHISTOCHEMICAL STUDY OF MUC1, MUC2 AND MUC5AC EXPRESSION IN PRIMARY BREAST CARCINOMA. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 Apr 25 ]; 11:EC30-EC34. Available from
Date of Submission: Jan 04, 2017
Date of Peer Review: Jan 30, 2017
Date of Acceptance: Feb 20, 2017
Date of Publishing: Apr 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
- PubMed Central® (PMC)New
- Academic Search Complete Database
- Chemical Abstracts Service
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Open J-Gate
- Popline (reproductive health literature)