Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Year : 2017 | Month : April | Volume : 11 | Issue : 4 | Page : ED05 - ED07

Oncogenic Osteomalacia: An Approach to Diagnosis with a Case Report

Biswajit Dey, Debasis Gochhait, Hema Subramanian, Madhusudhanan Ponnusamy

1. Senior Resident, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. 2. Assistant Professor, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. 3. Junior Resident, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. 4. Assistant Professor, Department of Nuclear Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

Correspondence Address :
Dr. Debasis Gochhait, Assistant Professor,
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER),
Puducherry-605006, India.
E-mail: publicationmail@rediffmail.com

Abstract

Oncogenic osteomalacia, also known as tumour induced osteomalacia, is a rare paraneoplastic syndrome caused by mesenchymal tumours secreting Fibroblast Growth Factor-23 (FGF-23). The characteristic biochemical findings include hypophosphatemia and low 1,25-dihydroxy vitamin D. The differential diagnosis for hypophosphatemia are varied. We present a case of oncogenic osteomalacia in a 29-year-old female, who presented with complaints of generalized diffuse bone pain and walking difficulty for six months duration. Thus, we have discussed the approach to diagnosis in such a case.

Keywords

Fibroblast growth factor-23, Phosphaturic mesenchymal tumour, Scintigraphy

How to cite this article :

Biswajit Dey, Debasis Gochhait, Hema Subramanian, Madhusudhanan Ponnusamy. ONCOGENIC OSTEOMALACIA: AN APPROACH TO DIAGNOSIS WITH A CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 Mar 28 ]; 11:ED05-ED07. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=April&volume=11&issue=4&page=ED05-ED07&id=9634

DOI and Others

DOI: 10.7860/JCDR/2017/25055.9634


Date of Submission: Oct 25, 2016
Date of Peer Review: Nov 16, 2016
Date of Acceptance: Dec 04, 2016
Date of Publishing: Apr 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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