Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Year : 2017 | Month : April | Volume : 11 | Issue : 4 | Page : ED23 - ED24

Anaplastic Pleomorphic Xanthoastrocytoma in a Case of Neurofibromatosis Type 1: A Case Report

K Thara, Reetika Sharma, G Thiagarajan, Anita Ramdas, Renu Gboy Varghese

1. Postgraduate, Department of Pathology, Pondicherry Institute of Medical Sciences, Puducherry, India. 2. Assistant Professor, Department of Pathology, Pondicherry Institute of Medical Sciences, Puducherry, India. 3. Professor, Department of Neurosurgery, Pondicherry Institute of Medical Sciences, Puducherry, India. 4. Professor, Department of Pathology, Pondicherry Institute of Medical Sciences, Puducherry, India. 5. Professor, Department of Pathology, Pondicherry Institute of Medical Sciences, Puducherry, India.

Correspondence Address :
Dr. K Thara,
Room no: 534, OPD block, Pondicherry Institute of Medical Sciences, Puducherry-605014, India.
E-mail: thara.keloth@gmail.com

Abstract

Pleomorphic Xanthoastrocytoma (PXA) is a rare brain tumour comprising only <1% of primary brain tumours which is seen in children and young adults. Only 9-20% of the PXA shows anaplastic features and this has a bad prognosis. PXA is a WHO grade II tumour while anaplastic PXA is a WHO grade III tumour. Neurofibromatosis type 1(NF1), which is an autosomal dominant condition, predisposes to tumours of the central nervous system; most of which are pilocytic astrocytomas. Association of PXA with NF1 is very rare and only a very few cases have been reported. Here, we present a case of 42-year-old male, a known case of NF1, with multiple neurofibromas, who presented with right sided hemiparesis, seizures and vomiting. The histopathology and immunohistochemistry features were suggestive of anaplastic PXA.

Keywords

CNS tumour, High grade, Glioblastoma, Immunohistochemistry

How to cite this article :

K Thara, Reetika Sharma, G Thiagarajan, Anita Ramdas, Renu Gboy Varghese. ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA IN A CASE OF NEUROFIBROMATOSIS TYPE 1: A CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 Apr 25 ]; 11:ED23-ED24. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=April&volume=11&issue=4&page=ED23-ED24&id=9713

DOI and Others

DOI: 10.7860/JCDR/2017/26685.9713


Date of Submission: Jan 10, 2017
Date of Peer Review: Jan 26, 2017
Date of Acceptance: Feb 20, 2017
Date of Publishing: Apr 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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