Anaplastic Pleomorphic Xanthoastrocytoma in a Case of Neurofibromatosis Type 1: A Case ReportCorrespondence Address :
Dr. K Thara,
Room no: 534, OPD block, Pondicherry Institute of Medical Sciences, Puducherry-605014, India.
Pleomorphic Xanthoastrocytoma (PXA) is a rare brain tumour comprising only <1% of primary brain tumours which is seen in children and young adults. Only 9-20% of the PXA shows anaplastic features and this has a bad prognosis. PXA is a WHO grade II tumour while anaplastic PXA is a WHO grade III tumour. Neurofibromatosis type 1(NF1), which is an autosomal dominant condition, predisposes to tumours of the central nervous system; most of which are pilocytic astrocytomas. Association of PXA with NF1 is very rare and only a very few cases have been reported. Here, we present a case of 42-year-old male, a known case of NF1, with multiple neurofibromas, who presented with right sided hemiparesis, seizures and vomiting. The histopathology and immunohistochemistry features were suggestive of anaplastic PXA.
CNS tumour, High grade, Glioblastoma, Immunohistochemistry
K Thara, Reetika Sharma, G Thiagarajan, Anita Ramdas, Renu Gboy Varghese. ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA IN A CASE OF NEUROFIBROMATOSIS TYPE 1: A CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 Apr 25 ]; 11:ED23-ED24. Available from
Date of Submission: Jan 10, 2017
Date of Peer Review: Jan 26, 2017
Date of Acceptance: Feb 20, 2017
Date of Publishing: Apr 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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