Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 5213

Original article / research
Year : 2017 | Month : April | Volume : 11 | Issue : 4 | Page : LC05 - LC07

Significance of Platelet Volume Indices in STEMI Patients: An Case-Control Study

Sravan K Reddy, Ranjan Shetty, Srujitha Marupuru, Nishanth Yedavalli, Kiran Shetty

1. Registrar, Department of Cardiology, Kasturba Medical College, Manipal, Karnataka, India. 2. Professor and Head, Department of Cardiology, Kasturba Medical College, Manipal, Karnataka, India. 3. Intern, Department of Pharmacy Practice, Kasturba Medical College, Manipal, Karnataka, India. 4. Intern, Department of Pharmacy Practice, Kasturba Medical College, Manipal, Karnataka, India. 5. PhD Scholar, Department of Cardiology, Manipal, Karnataka, India.

Correspondence Address :
Dr. Sravan K Reddy,
Registrar, Department of Cardiology, Kasturba Medical College, Manipal-576104, Karnataka, India.
E-mail: sravanr69@gmail.com

Abstract

Introduction: Platelets have been well known contributors in the pathogenesis of cardiovascular disorders such as atherosclerosis and its complications such as acute Myocardial Infarction (MI).

Aim: To study the changes in platelet volume indices and platelet count in ST-Elevated Myocardial Infarction (STEMI) and assess their usefulness in predicting coronary events.

Materials and Methods: A case-control observational study was carried out on 173 cases diagnosed with STEMI and 191 controls from January 2015 to December 2015, considering the inclusion and exclusion criteria. In total, 364 patients were included, 173 patients with STEMI, from those patients admitted to the intensive care unit and the emergency ward. In addition, 191 healthy non diabetic non hypertensive age-matched controls were enrolled.

Results: The mean age of cases was 59.4±11.9 years and of controls were 55.25±8.5 years. Males (74.6%) had higher incidence of STEMI then females (25.4%). The Mean Platelet Volume (MPV) was significantly higher in patients with STEMI (10.2±2.8) as compared to controls (8.5±6.9). The Platelet Distribution Width (PDW) was also significantly higher in cases compared to controls (p<0.05). According to Pearson correlation analysis, the positive relationship determined between MPV and Gensini score was statistically significant (p < 0.001, r = 0.132).

Conclusion: High MPV and PDW seem to be an independent risk factor for STEMI and correlated with the severity of the STEMI. They can be used as a simple, reliable, and economical method for predicting an impending acute coronary event.

Keywords

Gensini score, Mean platelet volume, Myocardial infarction, Prognostic aid

How to cite this article :

Sravan K Reddy, Ranjan Shetty, Srujitha Marupuru, Nishanth Yedavalli, Kiran Shetty. SIGNIFICANCE OF PLATELET VOLUME INDICES IN STEMI PATIENTS: AN CASE-CONTROL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 Apr 28 ]; 11:LC05-LC07. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=April&volume=11&issue=4&page=LC05-LC07&id=9622

DOI and Others

DOI: 10.7860/JCDR/2017/24963.9622


Date of Submission: Oct 21, 2016
Date of Peer Review: Nov 21, 2016
Date of Acceptance: Dec 30, 2016
Date of Publishing: Apr 01, 2017


Financial OR OTHER COMPETING INTERESTS: None.

JCDR is now Monthly and more widely Indexed .
  • PubMed Central® (PMC)New
  • Academic Search Complete Database
  • Chemical Abstracts Service
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhostNew
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Open J-Gate
  • Popline (reproductive health literature)
  • SCOPUS
  • www.omnimedicalsearch.com