Inhaled Insulin - Current Direction of Insulin ResearchCorrespondence Address :
Dr. Rashmi Ranjan Mohanty,
Department of Medicine, AIIMS, Bhubaneswar, Odisha-751003, India.
Diabetes Mellitus (DM) is a metabolic disorder characterized by relative or absolute deficiency of insulin, resulting in hyperglycemia. Subcutaneous insulin and Oral Hypoglycaemic Agents (OHA) constitute the main treatment option for DM. Insulin is administered by injection or continuous infusion to control glucose levels mainly in Type I diabetes. Newer routes both oral and non oral, for insulin administration are current direction of insulin research as insulin injection therapy is burdensome and painful for many patients. Inhalational insulin is an attractive alternative for systemic administration of insulin given its accessibility and large alveolar-capillary network of lungs for drug absorption. Afrezza, inhaled insulin has been recently approved by Food and Drug Administration (FDA). It is a new, quicker acting inhalable insulin with a different and safer pharmacokinetic profile in comparison to previously failed inhaled form of insulin.
Afrezza, Diabetes, Exubera
Rashmi Ranjan Mohanty, Smita Das. INHALED INSULIN - CURRENT DIRECTION OF INSULIN RESEARCH. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 May 29 ]; 11:OE01-OE02. Available from
Date of Submission: Sep 08, 2016
Date of Peer Review: Nov 28, 2016
Date of Acceptance: Jan 06, 2017
Date of Publishing: Apr 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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