Neonatal Hyperthyroidism with Fulminant Liver Failure: A Case ReportCorrespondence Address :
Dr. Mohammed Hasosah,
Department of Paediatrics, Paediatric Consultant,
King Abdul-Aziz Medical City, National Guard Hospital, PO Box: 8202, Jeddah 21482. Saudi Arabia.
Neonatal hyperthyroidism is a rare disease that is seen in infants born to mothers with Graves’ disease. Hepatic manifestation of neonatal hyperthyroidism is extremely rare. We describe a neonate with fulminant liver failure secondary to neonatal hyperthyroidism caused by maternal Graves’s disease. The baby was admitted with low birth weight and hepatosplenomegaly. At day 2 of life, the baby was irritable and he developed respiratory distress and fulminant hepatic failure which required mechanical ventilation. All investigations of obstructive, infectious and metabolic causes of hepatic failure were negative. His hepatic dysfunction improvement was correlated with initiation carbimazole as anti-thyroid medication. The conjugated hyperbilirubinemia, liver enzymes and International Normalised Ratio (INR) were gradually improved with normalization by eight weeks. This case has been reported to illustrate lessons learnt for early identification of neonate with hyperthyroidism as potential cause of cholestasis is important, because delayed treatment of hyperthyroidism might lead to irreversible consequences such as mental retardation or even death due to liver failure.
Cholestasis, Graves disease, Liver diseases
Mohammed Hasosah, Khalid AlSaleem, Mansour Qurashi, Abdullah Alzaben. NEONATAL HYPERTHYROIDISM WITH FULMINANT LIVER FAILURE: A CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 Apr 25 ]; 11:SD01-SD02. Available from
Date of Submission: May 19, 2016
Date of Peer Review: Jul 18, 2016
Date of Acceptance: Aug 09, 2016
Date of Publishing: Apr 01 2017
Financial OR OTHER COMPETING INTERESTS: None.
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