Cloves Syndrome: Severe Neonatal PresentationCorrespondence Address :
Dr. Silvana Acosta,
Cardenal Newman 821, Las Condes, Santiago, Chile.
Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi and Spinal Abnormalities (CLOVES syndrome) is a newly described and rare overgrowth disorder with serious morbidity. The course of this disease is not well understood and few cases have been reported among neonates. Moreover, not all of the signs of this syndrome are present at birth, making a high index of suspicion necessary. We present a cohort of three newborns with CLOVES syndrome who died due to septic and hemodynamic complications directly related to extensive vascular malformations. We discuss the clinical presentation in the neonatal period and propose a clinical classification.
Lipodystrophy, Neonatal, Vascular malformation
Silvana Acosta, Viviana Torres, María Paulos, Ignacio Cifuentes. CLOVES SYNDROME: SEVERE NEONATAL PRESENTATION. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 May 29 ]; 11:TR01-TR03. Available from
Date of Submission: Aug 29, 2016
Date of Peer Review: Sep 21, 2016
Date of Acceptance: Oct 14, 2016
Date of Publishing: Apr 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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