The Effect of Sevoflurane Plus Propofol on Pain and Complications after Laminectomy: A Randomized Double Blind Clinical TrialCorrespondence Address :
Dr. Fatemeh Najafi,
MSc of Nursing, Ilam University of Medical Science, Ilam, Iran.
Introduction: Pain is one of the most important reasons for the patients concern after surgery. The perfect sedative should have properties like rapid onset, least pain and adverse effects.
Aim: To assess the effect of sevoflurane plus propofol on postoperative pain, haemodynamic stability and complication after lumbar disc surgery.
Materials and Methods: This was a randomized double- blind clinical trial. A total of 75 patients scheduled for elective lumbar disc surgery with simple random sampling design received sevoflurane (n=25, induced with Thiopentone and maintained with sevoflurane), propofol (n=25, induced and maintained with propofol) and sevoflurane plus propofol (n=25, induced with propofol and maintained with sevoflurane). Visual Analog Scale (VAS) was used to determine the intensity of postoperative pain. Complications after surgery and haemodynamic changes during surgery were recorded.
Results: The mean pain intensity and morphine consumption in the sevoflurane plus propofol group was lower compared to the propofol and sevoflurane groups at different intervals (p<0.001). The prevalence of shivering, nausea and vomiting in the sevoflurane plus propofol group was 24%, 28%, 28% respectively vs sevoflurane group 32%, 60%, 48% respectively and propofol group 32%, 16%, 12% respectively with p-value > 0.05, <0.001, <0.05 respectively. The mean blood pressure and heart rate were significantly lower in the sevoflurane plus propofol group compared to the propofol and sevoflurane groups (p<0.001).
Conclusion: According to the effect on pain and complications after lumbar disc surgery sevoflurane plus propofol can be regarded as safe and alternative drug in general anaesthesia for these patients.
Anaesthesia, Lumbar disc surgery, Visual analog scale
Aminolah Vasigh, Fatemeh Najafi, Molouk Jaafarpour, Java Javaher Khajavavikhan, Ali Khani. THE EFFECT OF SEVOFLURANE PLUS PROPOFOL ON PAIN AND COMPLICATIONS AFTER LAMINECTOMY: A RANDOMIZED DOUBLE BLIND CLINICAL TRIAL. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 Jun 24 ]; 11:UC05-UC08. Available from
Date of Submission: Aug 15, 2016
Date of Peer Review: Sep 22, 2016
Date of Acceptance: Nov 28, 2016
Date of Publishing: Apr 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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