Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : April | Volume : 11 | Issue : 4 | Page : ZC68 - ZC72

Formulation and Evaluation of Sol-Gel Drug Delivery System for Intracanal pH Sensitive Controlled Delivery of Chlorhexidine

Kapil Gandhi, Radha Srikrishna Maganti, Harsimrankaur, Ks Vinod, Pratik Verma

1. Professor, Department of Pedodontics and Preventive Dentistry, Inderprastha Dental College and Hospital, Ghaziabad, Uttar Pradesh, India. 2. General Manager, Department of Research and Development, Sai Life Sciences Limited, Shameerpet, Hyderabad, India. 3. Reader, Department of Pedodontics and Preventive Dentistry, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India. 4. Professor, Department of Oral Pathology and Microbiology, Triveni Institute of Dental Sciences, Hospital and Research Centre, Bilaspur, Chhattisgarh, India. 5. Senior Lecturer, Department of Orthodontics and Dentofacial Orthopaedics, Rama Dental College and Hospital, Kanpur, Uttar Pradesh, India.

Correspondence Address :
Dr. Kapil Gandhi,
Professor, Department of Pedodontics and Preventive Dentistry, Inderprastha Dental College and Hospital,
46/1, SiteIV, Industrial Area, Sahibabad Ghaziabad, Uttar Pradesh-201010, India.
E-mail: drkapilgandhi@gmail.com

Abstract

Introduction: Persistence of viable micro-organisms even after thorough chemomechanical debridement has been cited as a major cause for endodontic failure. Chlorhexidine is a drug, which has shown marked efficacy against Enterococcus faecalis and Candida spp., which are mostly accounted for endodontic failure and it has demonstrated high degree of substantivity to dentin by adsorption. Another issue with chlorhexidine and other intracanal medicaments is the excessive or premature peaking of the drug leading to possible side effects.

Aim: The objective of this experimental work undertaken was to formulate a pH sensitive sol-gel sustained drug delivery system containing chlorhexidine.

Materials and Methods: The formulations were prepared using different concentrations of GELRITE® (0.1% and 0.2%) and Chlorhexidine (0.1% and 0.2%). The prepared solutions were evaluated for pharmacological properties like sterility test, viscosity, drug content, drug release characteristics, drug excipient compatible study.

Results: The drug excipient compatibility studies showed no interaction between the excipient and the active constituent. The microbial analysis showed good efficacy against the test micro-organisms and Minimum Inhibitory Concentration (MIC) values against Candida albicans (ATCC® 14053™) was observed as 4 µl/ml for both formulation containing 0.1% and 0.2% of GELRITE® Gellan (polymer). Whereas, MIC values against Enterococcus faecalis was observed to be 3.2 µl/ml and 6 µl/ml for formulation containing 0.1% and 0.2% of GELRITE® Gellan (polymer) respectively.

Conclusion: From the present study, it could be successfully demonstrated that sol-gel formulations can be simple, easy to administer mode of intracanal drug delivery system. Localized pH changes present within the canal can trigger sol-gel conversion thereby releasing the drug in sustained manner with less toxicity and side effects.

Keywords

Endodontic failure, Enterococcus faecalis, Intracanal medicament

How to cite this article :

Kapil Gandhi, Radha Srikrishna Maganti, Harsimrankaur, Ks Vinod, Pratik Verma. FORMULATION AND EVALUATION OF SOL-GEL DRUG DELIVERY SYSTEM FOR INTRACANAL PH SENSITIVE CONTROLLED DELIVERY OF CHLORHEXIDINE. Journal of Clinical and Diagnostic Research [serial online] 2017 April [cited: 2017 May 29 ]; 11:ZC68-ZC72. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=April&volume=11&issue=4&page=ZC68-ZC72&id=9693

DOI and Others

DOI: 10.7860/JCDR/2017/26061.9693


Date of Submission: Dec 16, 2016
Date of Peer Review: Jan 23, 2017
Date of Acceptance: Mar 16, 2017
Date of Publishing: Apr 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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