CD44 Expression in Meningioma and its Correlation with Proliferation IndicesCorrespondence Address :
Dr. Rasha Ahmed Khairy,
119 Al Ahram Street, Giza, Egypt.
Introduction: CD44 is a cell adhesion molecule assumed to be related to tumour invasion and metastatic ability and is expressed in variety of tumours including meningiomas.
Aim: To evaluate the immunohistochemical expression of CD44 in variable grades and variants of meningioma and to correlate the results with Ki-67 proliferation index and available clinicopathologic variables.
Materials and Methods: A total of 40 meningioma cases were studied for immunohistochemical expression of CD44 and Ki-67 and correlated with different clinicopathologic variables. A p-value less than 0.05 was considered statistically significant.
Results: CD44 was markedly expressed in high grade (II and III) meningioma (81.8%) compared to grade I (18.2%) and that was statistically significant (p<0.001). Ki-67 proliferation activity was significantly correlated with meningioma grade (p<0.001) and brain invasiveness (p=0.033). Moreover, statistically positive correlation (p=0.01) was reported between CD44 and Ki-67 proliferative activity. No statistically significant correlation was detected between CD44 or Ki-67 expression and patients’ age, sex, and tumour recurrence rate (p>0.05).
Conclusion:We concluded that CD44 is a marker of aggressiveness in meningioma as it was significantly highly expressed in grade II and III meningioma and was, positively correlated with higher Ki-67 proliferation indices. Therefore, researches should be carried out to identify the role of CD44 targeted therapy in atypical and anaplastic meningiomas as done in other tumours e.g., breast cancer.
Immunohistochemical, Ki-67, Meningioma
Rasha Ramadan Mostafa, Rasha Ahmed Khairy. CD44 EXPRESSION IN MENINGIOMA AND ITS CORRELATION WITH PROLIFERATION INDICES. Journal of Clinical and Diagnostic Research [serial online] 2017 August [cited: 2017 Oct 24 ]; 11:EC12-EC15. Available from
Date of Submission: Mar 27, 2017
Date of Peer Review: Apr 25, 2017
Date of Acceptance: May 15, 2017
Date of Publishing: Aug 01, 2017
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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