Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Year : 2017 | Month : August | Volume : 11 | Issue : 8 | Page : ED06 - ED07

A Rare Case of Primary Plasma Cell Leukaemia with Monosomy X

Smita Surendra Masamatti, Aparna Narasimha, Archana C Shetty, C Vijaya

1. Assistant Professor, Department of Pathology, Sapthagiri Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India. 2. Professor, Department of Pathology, Sapthagiri Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India. 3. Associate Professor, Department of Pathology, Sapthagiri Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India. 4. Professor and Head, Department of Pathology, Sapthagiri Institute of Medical Sciences and Research Centre, Bengaluru, Karnataka, India.

Correspondence Address :
Dr. Smita Surendra Masamatti,
3rd Floor, Sapthagiri Medical College, Bengaluru-560090, Karnataka, India.
Email: smitamas@yahoo.co.in

Abstract

Primary Plasma Cell Leukaemia (pPCL) is a very rare and aggressive subtype of plasma cell dyscrasias with a very poor outcome and characterized by presence of >2x109/l circulating plasma cells. Overall incidence being 1%-2% of all malignant plasma cell diseases and 0.9% of all acute leukaemias. Patients with primary and secondary PCL have similar clinical features but differences do exist. Here we report a rare and interesting case diagnosed as primary PCL in a 44-year-old female with unusual clinical presentation and complex karyotyping. Her serum electrophoresis showed a monoclonal IgG component and immunohistochemistry of bone marrow plasma cells showed CD 38+ and CD 20-. The patient initially responded partially for combination chemotherapy, but succumbed after 20 days of diagnosis. We are presenting this case to highlight the importance of early diagnosis of such haematological malignancies in settings where treatment options like stem cell transplantation are limited.

Keywords

Acute renal failure, Cytogenetics, Prognosis

How to cite this article :

Smita Surendra Masamatti, Aparna Narasimha, Archana C Shetty, C Vijaya. A RARE CASE OF PRIMARY PLASMA CELL LEUKAEMIA WITH MONOSOMY X. Journal of Clinical and Diagnostic Research [serial online] 2017 August [cited: 2017 Aug 20 ]; 11:ED06-ED07. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=August&volume=11&issue=8&page=ED06-ED07&id=10367

DOI and Others

DOI: 10.7860/JCDR/2017/28512.10367

Date of Submission: Mar 20, 2017
Date of Peer Review: Mar 21, 2017
Date of Acceptance: May 09, 2017
Date of Publishing: Aug 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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