Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 16547

Case report
Year : 2017 | Month : August | Volume : 11 | Issue : 8 | Page : ED08 - ED10

Amelanotic Signet Ring Cell Melanoma Presenting as Breast Lump- A Diagnostic Conundrum

Prasath Sathiah, Debasis Gochhait, Subathra Adithan, Sandhya Umamahesweran, Priyadarshini Dehuri

1. Senior Resident, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. 2. Assistant Professor, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. 3. Assistant Professor, Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. 4. Junior Resident, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. 5. Senior Resident, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Correspondence Address :
Dr. Debasis Gochhait,
Department of Pathology, Institute Block, JIPMER-605006, Puducherry, India.
E-mail: debasis.go@gmail.com

Abstract

Amelanotic signet ring cell melanoma is one of the rare variants of malignant melanoma. Here we are presenting a case of a 58-year-old female with chief complaints of swelling in the left sternal region/breast, and right cervical region. Contrast Enhanced CT scan showed the two well circumscribed lobular mass lesions with central necrosis in the left breast. The radiologist opined the lesions as intramammary nodes. Biopsy from the larger breast mass lesion showed a tumour with cells arranged in a pattern less and discohesive manner. These tumour cells had a predominantly signet ring morphology along with markedly pleomorphic tumour cells and giant cells. These tumour cells were negative for pan CK and positive for S100, HMB45. So the case was diagnosed as metastatic amelanotic malignant melanoma with signet ring morphology.

Keywords

Lymph node, Immunohistochemistry, Metastasis, S100

How to cite this article :

Prasath Sathiah, Debasis Gochhait, Subathra Adithan, Sandhya Umamahesweran, Priyadarshini Dehuri. AMELANOTIC SIGNET RING CELL MELANOMA PRESENTING AS BREAST LUMP- A DIAGNOSTIC CONUNDRUM. Journal of Clinical and Diagnostic Research [serial online] 2017 August [cited: 2017 Aug 18 ]; 11:ED08-ED10. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=August&volume=11&issue=8&page=ED08-ED10&id=10368

DOI and Others

DOI: 10.7860/JCDR/2017/28774.10368

Date of Submission: Mar 29, 2017
Date of Peer Review: May 19, 2017
Date of Acceptance: May 11, 2017
Date of Publishing: Aug 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

JCDR is now Monthly and more widely Indexed .
  • PubMed Central® (PMC)New
  • Academic Search Complete Database
  • Chemical Abstracts Service
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhostNew
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Open J-Gate
  • Popline (reproductive health literature)
  • SCOPUS
  • www.omnimedicalsearch.com