Amelanotic Signet Ring Cell Melanoma Presenting as Breast Lump- A Diagnostic ConundrumCorrespondence Address :
Dr. Debasis Gochhait,
Department of Pathology, Institute Block, JIPMER-605006, Puducherry, India.
Amelanotic signet ring cell melanoma is one of the rare variants of malignant melanoma. Here we are presenting a case of a 58-year-old female with chief complaints of swelling in the left sternal region/breast, and right cervical region. Contrast Enhanced CT scan showed the two well circumscribed lobular mass lesions with central necrosis in the left breast. The radiologist opined the lesions as intramammary nodes. Biopsy from the larger breast mass lesion showed a tumour with cells arranged in a pattern less and discohesive manner. These tumour cells had a predominantly signet ring morphology along with markedly pleomorphic tumour cells and giant cells. These tumour cells were negative for pan CK and positive for S100, HMB45. So the case was diagnosed as metastatic amelanotic malignant melanoma with signet ring morphology.
Lymph node, Immunohistochemistry, Metastasis, S100
Prasath Sathiah, Debasis Gochhait, Subathra Adithan, Sandhya Umamahesweran, Priyadarshini Dehuri. AMELANOTIC SIGNET RING CELL MELANOMA PRESENTING AS BREAST LUMP- A DIAGNOSTIC CONUNDRUM. Journal of Clinical and Diagnostic Research [serial online] 2017 August [cited: 2017 Aug 18 ]; 11:ED08-ED10. Available from
Date of Submission: Mar 29, 2017
Date of Peer Review: May 19, 2017
Date of Acceptance: May 11, 2017
Date of Publishing: Aug 01, 2017
FINANCIAL OR OTHER COMPETING INTERESTS: None.
- PubMed Central® (PMC)New
- Academic Search Complete Database
- Chemical Abstracts Service
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Open J-Gate
- Popline (reproductive health literature)