Visceral Adiposity Index and the Degree of Hepatic Fibrosis and Inflammation in Egyptian Patients with Chronic Hepatitis CCorrespondence Address :
Dr. Inas Elkhedr Mohamed,
14 Alzohour street, Orouba, Nozha, Cairo, Egypt.
Introduction: Many clinical studies suggest a direct association between hepatic fat content and visceral adiposity and the progression of fibrosis.
Aim: This work aims to clarify the relation between the Visceral Adiposity Index (VAI) and severity of necroinflammatory activity and liver fibrosis in Egyptian patients with chronic Hepatitis C Virus (HCV) infection.
Materials and Methods: A cross-sectional study, over a period of six months, was performed on 50 chronic HCV patients subjected to routine laboratory investigations, abdominal ultrasonography, measurement of Waist Circumference (WC), calculation of Body Mass Index (BMI) and VAI, ultrasound guided liver biopsy and assessment of hepatic fibrosis by METAVIR staging.
Results: A total of 50 HCV positive patients, 29 (58%) males and 21 (42%) females were included in the study. Age ranged from 29-60 years (44.4±8.4). BMI was ranged from 20.3 to 41.4 kg/m2 (31.7±5.5). VAI for males was 0.4±0.2 and for females was 0.5±0.3. There were significant positive correlations between VAI and BMI, Triglycerides (TG), fibrosis stages, grades of liver inflammation and FIB-4 Fibrosis-4 score. There were significant negative correlations between VAI and high density lipoprotein, platelets and haemoglobin.
Conclusion: There is an association between visceral obesity represented by VAI and the severity of hepatic inflammatory response in chronic hepatitis C patients. Other studies are recommended to measure the clinical implication of visceral obesity on the response to the novel directly acting antivirals.
Liver fibrosis, Viral hepatitis, Visceral obesity
Zainab ahmed ali-eldin, fatma ahmed ali-eldin, inas elkhedr mohamed. VISCERAL ADIPOSITY INDEX AND THE DEGREE OF HEPATIC FIBROSIS AND INFLAMMATION IN EGYPTIAN PATIENTS WITH CHRONIC HEPATITIS C. Journal of Clinical and Diagnostic Research [serial online] 2017 August [cited: 2017 Oct 19 ]; 11:OC11-OC14. Available from
Date of Submission: Mar 17, 2017
Date of Peer Review: May 12, 2017
Date of Acceptance: Jun 27, 2017
Date of Publishing: Aug 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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