Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : December | Volume : 11 | Issue : 12 | Page : SC01 - SC04

Associations of Maternal Serum Zonulin and Elements Concentrations with Neonatal Birth Weight: A Case-Control Study

Seyed Ahmad Hosseini, Omid Kiani Ghalesardi, ZahraKamaei, Shekoofeh Aghili, DamoonAshtary-Larky, Seyed Saheb Hoseininejad, MatinGhanavati, Meysam Alipour

1. Assistant Professor, Department of Nutrition, Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khozestan, Iran. 2. Postgraduate, Department of Hematology, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khozestan, Iran. 3. Research Scholar, Department of Nutrition, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khozestan, Iran. 4. Research Scholar, Department of Nutrition, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khozestan, Iran. 5. Postgraduate, Department of Biochemistry, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khozestan, Iran. 6. Chief of Staff, Department of General Surgery, Sina Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khozestan, Iran. 7. PhD Student, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid

Correspondence Address :
Dr. Meysam Alipour,
PhD Student, Department of Nutrition, Nutrition and Metabolic Diseases Research Center,
Ahvaz Jundishapur University of Medical Sciences, P. O. Box: 159613-5715794, Ahvaz, Khozestan, Iran.
E-mail: Meysam.aalipour@yahoo.com

Abstract

Introduction: Intake of micronutrients and zonulin levels (as a marker for intestinal permeability) during pregnancy can be effective on birth weight of infants. However, no studies have investigated the relationship between the infants birth weight and maternal zonulin level.

Aim: This study aimed to compare the zonulin levels and maternal trace elements in infants with low birth weight (LBW) and Normal Birth Weight (NBW) and its relationship between the Level of zonulin and maternal elements with weight, length and head circumference of infants.

Materials and Methods: In this study, 368 infants were divided into two groups: case (n=82) with birth weight of <2500 gm and control (n=286) with birth weight of =2500 gm. Maternal zonulin, zinc, calcium, copper and iron levels were evaluated. Weight, length and head circumference of infants were measured. The maternal serum level zonulin and micronutrients between the two groups were assessed using Student t-test or Chi-squared test and the relationship between variables using Spearman’s rank correlation.

Results: A significant difference was seen in the maternal zonulin and zinc serum levels between the LBW and the NBW infants (P <0.05). No significant difference was observed in the calcium, copper, and iron levels between the two groups. A significant positive relationship was seen between maternal serum zonulin and zinc concentration with the birth weight of the LBW infants (respectively r=0.45 and r=0.41) (P <0.05). No relationship was seen between maternal serum zonulin and zinc concentration with the length and head circumference of the infants.

Conclusion: The results showed that the maternal serum Zn level is associated with the infants birth weight. In addition, intestinal permeability, as a new factor could affect the birth weight and birth rate of the LBW infants. Further studies in this area are recommended.

Keywords

Nutrient deficiency, Low birth, Trace elements

How to cite this article :

Seyed Ahmad Hosseini, Omid Kiani Ghalesardi, ZahraKamaei, Shekoofeh Aghili, DamoonAshtary-Larky, Seyed Saheb Hoseininejad, et al.. ASSOCIATIONS OF MATERNAL SERUM ZONULIN AND ELEMENTS CONCENTRATIONS WITH NEONATAL BIRTH WEIGHT: A CASE-CONTROL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2017 December [cited: 2017 Dec 18 ]; 11:SC01-SC04. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=December&volume=11&issue=12&page=SC01-SC04&id=10936

DOI and Others

DOI: 10.7860/JCDR/2017/27820.10936

Date of Submission: Feb 25, 2017
Date of Peer Review: Mar 28, 2017
Date of Acceptance: Jul 01, 2017
Date of Publishing: Dec 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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