Significant Haematogone Proliferation Mimicking Relapse in Acute Lymphoblastic Leukaemia on TherapyCorrespondence Address :
Dr. Smeeta Gajendra,
Department of Pathology and Laboratory Medicine, Medanta-The Medicity, Sector – 38, Gurgaon, Haryana, India.
Haematogones are benign B lymphoid precursors which may mimic neoplastic lymphoblasts and pose diagnostic difficulty especially when the percentage of haematogones exceeds 10% in the bone marrow. Flow cytometric analysis with combination of CD19/CD10/CD20/CD34/CD38/CD58 can be used to differentiate the two depending upon the difference in the fluorescence intensity between blasts and haematogones. We hereby present a case of CALLA positive ALL, in which patient presented with haematogone proliferation in bone marrow after 6 months of chemotherapy mimicking relapse. The distinction was made on flow cytometric immunophenotyping by using optimal antibody combination. Distinction of benign haematogones from neoplastic lymphoblasts is essential for disease management in cases of post chemotherapy or post marrow transplant, especially in patients of ALL. Flow cytometric immunophenotyping is reliable to distinguish haematogones from residual lymphoblasts in almost all cases when optimal antibody combinations are used.
ALL, Benign B lymphoid precursors, Flow cytometry, MRD
Smeeta Gajendra, Ruchira Misra, Pranav Dorwal, Rashi Sharma, Ritesh Sachdev. SIGNIFICANT HAEMATOGONE PROLIFERATION MIMICKING RELAPSE IN ACUTE LYMPHOBLASTIC LEUKAEMIA ON THERAPY. Journal of Clinical and Diagnostic Research [serial online] 2017 February [cited: 2017 Feb 19 ]; 11:ED01-ED03. Available from
Date of Submission: Aug 19, 2016
Date of Peer Review: Sep 28, 2016
Date of Acceptance: Oct 29, 2016
Date of Publishing: Feb 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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