Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Case report
Year : 2017 | Month : February | Volume : 11 | Issue : 2 | Page : ED01 - ED03

Significant Haematogone Proliferation Mimicking Relapse in Acute Lymphoblastic Leukaemia on Therapy

Smeeta Gajendra, Ruchira Misra, Pranav Dorwal, Rashi Sharma, Ritesh Sachdev

1. Associate Consultant, Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India. 2. Consultant, Department of Paediatric Hemat-Oncology, Medanta - The Medicity, Gurgaon, Haryana, India. 3. Associate Consultant, Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India. 4. Senior Resident, Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India. 5. Senior Consultant, Department of Pathology and Laboratory Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.

Correspondence Address :
Dr. Smeeta Gajendra,
Department of Pathology and Laboratory Medicine, Medanta-The Medicity, Sector – 38, Gurgaon, Haryana, India.
E-mail: drsmeeta@gmail.com

Abstract

Haematogones are benign B lymphoid precursors which may mimic neoplastic lymphoblasts and pose diagnostic difficulty especially when the percentage of haematogones exceeds 10% in the bone marrow. Flow cytometric analysis with combination of CD19/CD10/CD20/CD34/CD38/CD58 can be used to differentiate the two depending upon the difference in the fluorescence intensity between blasts and haematogones. We hereby present a case of CALLA positive ALL, in which patient presented with haematogone proliferation in bone marrow after 6 months of chemotherapy mimicking relapse. The distinction was made on flow cytometric immunophenotyping by using optimal antibody combination. Distinction of benign haematogones from neoplastic lymphoblasts is essential for disease management in cases of post chemotherapy or post marrow transplant, especially in patients of ALL. Flow cytometric immunophenotyping is reliable to distinguish haematogones from residual lymphoblasts in almost all cases when optimal antibody combinations are used.

Keywords

ALL, Benign B lymphoid precursors, Flow cytometry, MRD

How to cite this article :

Smeeta Gajendra, Ruchira Misra, Pranav Dorwal, Rashi Sharma, Ritesh Sachdev. SIGNIFICANT HAEMATOGONE PROLIFERATION MIMICKING RELAPSE IN ACUTE LYMPHOBLASTIC LEUKAEMIA ON THERAPY. Journal of Clinical and Diagnostic Research [serial online] 2017 February [cited: 2017 Mar 24 ]; 11:ED01-ED03. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=February&volume=11&issue=2&page=ED01-ED03&id=9190

DOI and Others

DOI: 10.7860/JCDR/2017/23650.9190


Date of Submission: Aug 19, 2016
Date of Peer Review: Sep 28, 2016
Date of Acceptance: Oct 29, 2016
Date of Publishing: Feb 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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