Primary Sarcomas of Thyroid Gland–Series of Three Cases with Brief Review of Spindle Cell Lesions of ThyroidCorrespondence Address :
Dr. Amita Jain Gupta,
Senior Resident, Department of Pathology, Maulana Azad Medical College, Delhi-110065, India.
Primary Malignant Fibrous Histiocytoma (MFH-T) and Leiomyosarcoma (LMS-T) of the thyroid gland are extremely rare tumors. Very few cases have been reported in the literature. Both entities occur more commonly in women than men. The closest clinical and histological differential diagnosis is anaplastic carcinoma of thyroid. We present three cases of rare primary sarcomas of thyroid gland. Case-1 was a 63-year-old woman and Case-2 was a 52-year-old woman. Both of them presented with a rapidly increasing thyroid mass clinically mimicking anaplastic carcinoma (AC-T). Both the patients developed pulmonary metastasis and succumbed to the illness soon after the diagnosis of MFH-T was made. Case 3 was 65-year-old woman with neck swelling since six months diagnosed as LMS-T. The present communication adds three new cases to the literature on sarcomas of thyroid gland with an emphasis on differential diagnosis of spindle cell lesions of thyroid. MFH-T and LMS-T needs to be differentiated from AC-T, metastatic sarcomas, spindle cell variant of medullary carcinoma, synovial sarcoma, fibrosarcoma; final diagnosis rests on histopathology and immunohistochemistry.
Leiomyosarcoma thyroid, Malignant fibrous histiocytoma thyroid, Sarcoma thyroid, Thyroid mass lesionmicrofollicles
Amita Jain Gupta, Meeta Singh, Poonam Rani, Nita Khurana, Anurag Mishra. PRIMARY SARCOMAS OF THYROID GLAND–SERIES OF THREE CASES WITH BRIEF REVIEW OF SPINDLE CELL LESIONS OF THYROID. Journal of Clinical and Diagnostic Research [serial online] 2017 February [cited: 2017 Jan 17 ]; 11:ER01-ER04. Available from
Date of Submission: Jul 28, 2016
Date of Peer Review: Aug 04, 2016
Date of Acceptance: Aug 31, 2016
Date of Publishing: Feb 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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