Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : July | Volume : 11 | Issue : 7 | Page : CC01 - CC04

Effect of Metaboreflex on Cardiovascular System in Subjects of Metabolic Syndrome

Pramita Dubey, Sunita Tiwari, Manish Bajpai, Kalpana Singh, Praveen Jha

1. Junior Resident, Department of Physiology, KGMU, Lucknow, Uttar Pradesh, India. 2. Professor and Head, Department of Physiology, KGMU, Lucknow, Uttar Pradesh, India. 3. Professor, Department of Physiology, KGMU, Lucknow, Uttar Pradesh, India. 4. Assistant Professor, Department of Biochemistry, KGMU, Lucknow, Uttar Pradesh, India. 5. Senior Resident, Department of Gastroenterology, RMLIMS, Lucknow, Uttar Pradesh, India.

Correspondence Address :
Dr. Sunita Tiwari,
Professor and Head, Department of Physiology, KGMU, Shahmina Road, Chowk-226003, Lucknow, Uttar Pradesh, India.
E-mail: sunita_kgmu@yahoo.com

Abstract

Introduction: Metaboreflex is a reflex in which muscle receptors send signals regarding metabolic (metabolites accumulation like lactic acid, potassium, adenosine) conditions of the muscles to nucleus tractus solitarius via afferent III and IV fibres to cause haemodynamic adjustments in order to regulate blood flow on the basis of the status of contracting muscle. Dysregulation in its mechanism in metabolic syndrome is demonstrated.

Aim: to study the effect of metaboreflex by both isometric and rhythmic handgrip exercise on CVS parameters {Blood Pressure (BP), Cardiac Output (CO) and Systemic Vascular Resistance (SVR)} in subjects of metabolic syndrome.

Materials and Methods: In this study, 27 subjects aged 25 to 45 years were enrolled after ethical clearance and proper consent. They were divided into: a) subjects without metabolic syndrome; and b) subjects with metabolic syndrome. Impedance cardiovasography was done to assess cardiac parameters (systolic and diastolic blood pressure, cardiac output, systemic vascular resistance). Pre-exercise parameters were assessed followed by isometric exercise and post-isometric exercise parameter measurement. Again after rest, rhythmic exercise was followed. Finally post exercise parameters were assessed. Student paired t-test for comparison between pre and post exercise parameters were done.

Results: Changes in diastolic BP following exercise were statistically significant in subjects without metabolic syndrome (p-value 0.01 and 0.001 following isometric and rhythmic exercise respectively). In subjects with metabolic syndrome also these changes were significant, but to a lesser extent (p-value 0.1 and 0.01 respectively for isometric and rhythmic exercise). Changes in systolic BP following exercise were statistically significant in subjects without metabolic syndrome (p-value 0.001 and 0.001 following isometric and rhythmic exercise respectively). In subjects with metabolic syndrome also these changes were significant (p-value 0.01 and 0.001 respectively for isometric and rhythmic exercise).

Conclusion: Diminished pressor response is found after exercise in subjects with metabolic syndrome.

Keywords

Autonomic nervous system, Cardiac parameters, Haemodynamics, Isometric exercise, Rhythmic exercise

How to cite this article :

Pramita Dubey, Sunita Tiwari, Manish Bajpai, Kalpana Singh, Praveen Jha. EFFECT OF METABOREFLEX ON CARDIOVASCULAR SYSTEM IN SUBJECTS OF METABOLIC SYNDROME. Journal of Clinical and Diagnostic Research [serial online] 2017 July [cited: 2017 Jul 20 ]; 11:CC01-CC04. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=July&volume=11&issue=7&page=CC01-CC04&id=10178

DOI and Others

DOI: 10.7860/JCDR/2017/27583.10178



Date of Submission: Feb 16, 2017
Date of Peer Review: Mar 17, 2017
Date of Acceptance: Apr 12, 2017
Date of Publishing: Jul 01, 2017


Financial OR OTHER COMPETING INTERESTS: None.

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