Clear Cell Adenocarcinoma of Female UrethraCorrespondence Address :
Dr. Ashwini Nivrutti Ghodke,
Assistant Professor, Department of Pathology, BJGMC, Pune-411001, Maharashtra, India.
Primary malignancies of female urethra are infrequent, constituting a fraction of less than 1% of genitourinary malignancies. Primary clear-cell adenocarcinoma of the urethra, is even rarer, that histomorphologically resembles clear-cell carcinoma of the female genital tract, occurs predominantly in women and is associated with a relatively poor prognosis. The histogenesis of this rare urethral neoplasm has not been completely determined. Various hypotheses concerning the origin have been postulated, including (1) diverticular origin (2) mullerian origin (3), glandular differentiation of urothelium or urothelial carcinoma. Here, we report a case of 67-year-old female with obstructive urinary symptoms and pain in abdomen, diagnosed with adenocarcinoma of urethra. Immunohistochemistry (IHC) workup of the tumour was done to find the origin of the tumour.
Immunohistochemistry, Mullerian rests, Urethral Carcinoma, Urogenital Tract
Sharada Raju Rane, Ashwini Nivrutti Ghodke, Sharvari Vishwasrao. CLEAR CELL ADENOCARCINOMA OF FEMALE URETHRA. Journal of Clinical and Diagnostic Research [serial online] 2017 July [cited: 2017 Jul 20 ]; 11:ED01-ED02. Available from
Date of Submission: Dec 25, 2016
Date of Peer Review: Jan 12, 2017
Date of Acceptance: Mar 27, 2017
Date of Publishing: Jul 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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