Evaluation of the Relationship between Serum 25-Hydroxyvitamin D and Hypertension in Hamadan, Iran-A Case Control StudyCorrespondence Address :
Dr. Mohamad Ali Seifrabiei,
Associate Professor, Department of Community Medicine, Hamadan Medical School,
Hamadan University of Medical Sciences, Hamadan, Zip Code: 6517838736, Iran.
Introduction: Hypertension or high blood pressure is one of the main reasons of fatality in the world. The role of vitamin D in developing hypertension has not been proved yet. Some studies have shown positive correlation between low serum vitamin D level and hypertension. Due to this fact, recognising hypertension risk factors such as potential impact of low serum vitamin D level seems to be required.
Aim: This study was conducted to evaluate potential impact of serum vitamin D level on hypertension.
Materials and Methods: This case-control study had 188 subjects including 55 cases suffering from hypertension and 133 controls with normal blood pressure in Hamadan, Iran. After taking the medical history and physical examination, 5 cc of their blood was taken to measure their serum 25-Hydroxyvitamin D [25(OH)D] level through ELISA test. Data analysis was done by version 16.0 of SPSS software and used independent sample t-test and Chi-square test for related comparisons.
Results: Mean and standard deviation of serum 25(OH)D level in patients suffering from hypertension was 13.10±9.7 ng/ml and in control group was 20.87±10.34 ng/ml. This variance was statistically significant (p<0.001). Mean serum 25(OH)D level in both case and control groups was measured after gender and age stratification. Mean serum 25(OH)D level in cases and controls was 13.12±11.4 ng/ml and 21.38±11.47 ng/ml in males (p=0.016) and 13.10±9.91 ng/ml and 19.19±10.55 ng/ml (p=0.004) in females, respectively. Mean serum 25(OH)D level in under 50-year-old was 10.82±8.73 ng/ml and 20.07±11.17 ng/ml in cases and controls respectively (p<0.001). In over 50-year-old, there was no significant relationship between mean serum 25(OH)D and blood pressure levels (p>0.05).
Conclusion: According to this study, reverse relationship between serum 25(OH)D and blood pressure levels was seen.
Vitamin deficiency, High blood pressure, Risk factor
Behshad Naghshtabrizi, Shiva Borzouei, Pedram Bigvand, Mohamadali Seifrabiei. EVALUATION OF THE RELATIONSHIP BETWEEN SERUM 25-HYDROXYVITAMIN D AND HYPERTENSION IN HAMADAN, IRAN-A CASE CONTROL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2017 July [cited: 2017 Jul 21 ]; 11:LC01-LC03. Available from
Date of Submission: Nov 19, 2016
Date of Peer Review: Jan 13, 2017
Date of Acceptance: May 11, 2017
Date of Publishing: Jul 01, 2017
Financial OR OTHER COMPETING INTERESTS: None
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