Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : July | Volume : 11 | Issue : 7 | Page : OC25 - OC29

Risk of GERD with Diabetes Mellitus, Hypertension and Bronchial Asthma – A Hospital based Retrospective Cohort Study

Sitara Nandyal, Sweta Suria, Bharti Chogtu, Dipanjan Bhattacharjee

1. Undergraduate Student, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India. 2. Undergraduate Student, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India. 3. Associate Professor, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India. 4. Postgraduate Candidate, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

Correspondence Address :
Dr. Bharti Chogtu,
Associate Professor, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka, India.
E-mail: bhartimagazine@gmail.com

Abstract

Introduction: The rise in Gastro-Esophageal Reflux Disease (GERD) prevalence appears to have coincided with a simultaneous increase in the prevalence of diabetes mellitus, hypertension and bronchial asthma amongst the Indian population. Despite being evaluated extensively for their role as a risk factor for GERD, till date this relationship has remained a debatable one. Moreover, literature available on such studies conducted within Indian population remains scarce.

Aim: The aim of the present study was to examine the risk of developing GERD in patients suffering from diabetes mellitus, hypertension and asthma in a Southern Indian population.The present retrospective, triple cohort and hospital based study was conducted by accessing the patient records from the medical records department of a tertiary care hospital in Southern India.

Materials and Methods: The patient’s records were accessed from the year 2011 onwards. Relative Risk (RR) was calculated to determine the risk of development of GERD with every disease. Chi-square test was used to determine the statistical significance of the relationship between each disease and the development of GERD. A p-value of <0.05 was considered statistically significant.

Results: In view of the time constraints as well as the limitations of the inclusion and exclusion criteria, data pertaining to only 40, 71 and 53 patients in Cohort 1 (diabetics), 2 (hypertensives) and 3 (bronchial asthmatics) respectively could be analyzed in the present study. The relative risk of GERD development was greater than 1 for patients belonging to Cohort 2 and 3, suggesting that the risk of GERD development is higher amongst hypertensives and asthmatics. Surprisingly, the diabetics (Cohort 1) were not associated with a high risk of GERD development. However, the relationship between any of the disease and GERD development was not statistically significant.

Conclusion: The present study found an increased risk of GERD development amongst patients suffering from hypertension and bronchial asthma, but not with diabetes mellitus.

Keywords

Gastro-esophageal reflux, Lifestyle diseases, Risk factors

How to cite this article :

Sitara Nandyal, Sweta Suria, Bharti Chogtu, Dipanjan Bhattacharjee. RISK OF GERD WITH DIABETES MELLITUS, HYPERTENSION AND BRONCHIAL ASTHMA – A HOSPITAL BASED RETROSPECTIVE COHORT STUDY. Journal of Clinical and Diagnostic Research [serial online] 2017 July [cited: 2017 Jul 20 ]; 11:OC25-OC29. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=July&volume=11&issue=7&page=OC25-OC29&id=10232

DOI and Others

DOI: 10.7860/JCDR/2017/25571.10232

Date of Submission: Nov 22, 2016
Date of Peer Review: Jan 14, 2017
Date of Acceptance: Jun 07, 2017
Date of Publishing: Jul 01, 2017


Financial OR OTHER COMPETING INTERESTS: None.

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