Prevalence of Acanthosis nigricans and Related Factors in Iranian Obese ChildrenCorrespondence Address :
Dr. Bahar Allahverdi,
Qarib St, Keshavarz Blvd, Tehran 1419733151, Iran.
Introduction: Recognition of Acanthosis nigricans (AN) provides important opportunities for screening of obesity syndrome, dyslipidemia, hypertension, and insulin resistance with diabetes mellitus 2. Considering the high prevalence of obesity among Iranian children, we designed this study to estimate the prevalence of AN and related laboratory factors in Iranian obese children.
Materials and Methods: Seventy-one obese children were enrolled in this study. Diagnosis of AN was done by clinical examination. Body mass index (BMI), fasting blood sugar, total cholesterol, triglycerides (TG), alanine aminotransferase, aspartate aminotransferase (AST), alkaline phosphatase, high- and low-density lipoprotein cholesterol, insulin, thyroid-stimulating hormone, free thyroxin (fT4), calcium, phosphorus, and 25-hydroxyvitamin D were measured with routine techniques. Collected data were compared between cases with AN and without AN. Independent t-test was used for comparison of variables.
Results: Twenty-five of children were female (35.2%). Forty-eight children (67.6%) had AN. In 20 cases (28.2%), homeostasis model assessment-insulin resistance (HOMA-IR) was <2.5, and in 51 (71.8%), HOMA-IR was more than 2.5. Mean BMI, insulin, HOMA-IR, TG, and AST levels were significantly higher in cases with AN.
Conclusion: Obese children with AN are at risk of developing diabetes. Hence early identification of this feature and precise evaluation of children is recommended.
BMI, Iran, Obesity, Pediatric
Fatemeh Sayarifard, Azadeh Sayarifard, Bahar Allahverdi, Sara Ipakchi, Mastaneh Moghtaderi, Bahareh Yaghmaei. PREVALENCE OF ACANTHOSIS NIGRICANS
AND RELATED FACTORS IN IRANIAN
OBESE CHILDREN. Journal of Clinical and Diagnostic Research [serial online] 2017 July [cited: 2017 Sep 21 ]; 11:SC05-SC07. Available from
Date of Submission: Oct 19, 2016
Date of Peer Review: Dec 22, 2016
Date of Acceptance: Apr 11, 2017
Date of Publishing: Jul 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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