Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : July | Volume : 11 | Issue : 7 | Page : SC05 - SC07

Prevalence of Acanthosis nigricans and Related Factors in Iranian Obese Children

Fatemeh Sayarifard, Azadeh Sayarifard, Bahar Allahverdi, Sara Ipakchi, Mastaneh Moghtaderi, Bahareh Yaghmaei

1. Assistant Professor, Pediatric Endocrinologist, Growth and Development Research Center, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. 2. Assistant Professor, Community Medicine Specialist, Growth and Development Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran. 3. Assistant Professor, Pediatric Gastroenterologist, Research Center for Pediatric Gastroenterology and Hepatology, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. 4. Medical doctor, Department of Paediatric, Tehran University of Medical Sciences, Tehran, Iran. 5. Pediatric Nephrologist, Chronic Kidney Disease Research Center, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. 6. Assistant Professor, Pediatric Intensifier, Children’s Medical Center, Pediatrics Center of Excellenc

Correspondence Address :
Dr. Bahar Allahverdi,
Qarib St, Keshavarz Blvd, Tehran 1419733151, Iran.
E-mail: bahar_allahverdi@yahoo.com

Abstract

Introduction: Recognition of Acanthosis nigricans (AN) provides important opportunities for screening of obesity syndrome, dyslipidemia, hypertension, and insulin resistance with diabetes mellitus 2. Considering the high prevalence of obesity among Iranian children, we designed this study to estimate the prevalence of AN and related laboratory factors in Iranian obese children.

Materials and Methods: Seventy-one obese children were enrolled in this study. Diagnosis of AN was done by clinical examination. Body mass index (BMI), fasting blood sugar, total cholesterol, triglycerides (TG), alanine aminotransferase, aspartate aminotransferase (AST), alkaline phosphatase, high- and low-density lipoprotein cholesterol, insulin, thyroid-stimulating hormone, free thyroxin (fT4), calcium, phosphorus, and 25-hydroxyvitamin D were measured with routine techniques. Collected data were compared between cases with AN and without AN. Independent t-test was used for comparison of variables.

Results: Twenty-five of children were female (35.2%). Forty-eight children (67.6%) had AN. In 20 cases (28.2%), homeostasis model assessment-insulin resistance (HOMA-IR) was <2.5, and in 51 (71.8%), HOMA-IR was more than 2.5. Mean BMI, insulin, HOMA-IR, TG, and AST levels were significantly higher in cases with AN.

Conclusion: Obese children with AN are at risk of developing diabetes. Hence early identification of this feature and precise evaluation of children is recommended.

Keywords

BMI, Iran, Obesity, Pediatric

How to cite this article :

Fatemeh Sayarifard, Azadeh Sayarifard, Bahar Allahverdi, Sara Ipakchi, Mastaneh Moghtaderi, Bahareh Yaghmaei. PREVALENCE OF ACANTHOSIS NIGRICANS AND RELATED FACTORS IN IRANIAN OBESE CHILDREN. Journal of Clinical and Diagnostic Research [serial online] 2017 July [cited: 2017 Sep 21 ]; 11:SC05-SC07. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=July&volume=11&issue=7&page=SC05-SC07&id=10203

DOI and Others

DOI: 10.7860/JCDR/2017/24902.10203



Date of Submission: Oct 19, 2016
Date of Peer Review: Dec 22, 2016
Date of Acceptance: Apr 11, 2017
Date of Publishing: Jul 01, 2017



Financial OR OTHER COMPETING INTERESTS: None.

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