Comparison of Intubating Conditions using Fentanyl plus Propofol Versus Fentanyl plus Midazolam during Fiberoptic LaryngoscopyCorrespondence Address :
Dr. Gurpreet Kaur Atwal,
44-B, New Kangra Colony, Near A.V. Partap School, Amritsar-143006, Punjab, India.
E-mail : email@example.com
Introduction: Awake nasal or oral flexible fiberoptic intubation is the airway management technique of choice in known or anticipated difficult airway, unstable cervical fracture, limited mouth opening (as in temporomandibular joint disease), mandibular-maxillary fixation and severe facial burns. Both optimal intubating condition and patient comfort are important for fiberoptic intubation. Optimal intubating conditions provided by an ideal sedation regimen would ensure haemodynamic stability, patient comfort, attenuation of airway reflexes and amnesia.
Aim: To compare the intubating conditions using fentanyl plus propofol versus fentanyl plus midazolam during fiberoptic laryngoscopy.
Materials and Methods: A prospective, comparative and randomized study was conducted on 60 patients of either gender aged between 18 and 60 years belonging to the American Society of Anaesthesiologists (ASA) grade-I or II scheduled for elective surgery. Patients were randomly allocated into two groups of 30 each. In group I, patients received i.v. fentanyl 1 µg/kg+ propofol 1 mg/kg to achieve an adequate level of sedation that is Ramsay Sedation Scale (RSS) score of 3. In group II, patients received i.v. fentanyl 1 µg/kg + midazolam 0.03 mg/kg to achieve RSS= score of 3. Haemodynamic parameters (heart rate, systolic and diastolic blood pressure, mean arterial pressure), SpO2, EtCO2, total comfort scale values and patient’s tolerance were assessed during preoxygenation, fiberscope insertion, and endotracheal intubation.
Results: Fentanyl plus midazolam group showed better patient comfort and maintenance of oxygen saturation than fentanyl plus propofol group during fiberoptic intubation.
Conclusion: Both fentanyl plus midazolam and fentanyl plus propofol regimes are suitable for fiberoptic intubation. Fentanyl plus midazolam appeared to offer better tolerance, preservation of an airway and spontaneous ventilation, while maintaining haemodynamic stability.
Patient’s tolerance, Ramsay sedation scale , SpO2, Total comfort scale
Parmod Kumar, Tripatpatpat Kaur, Gurpreet Kaur Atwal, Jatatinderpapaul Singh Bhupapal, Ajay Kumar Basra. COMPARISON OF INTUBATING CONDITIONS USING FENTANYL PLUS PROPOFOL VERSUS FENTANYL PLUS MIDAZOLAM DURING FIBEROPTIC LARYNGOSCOPY. Journal of Clinical and Diagnostic Research [serial online] 2017 July [cited: 2017 Sep 20 ]; 11:UC21-UC24. Available from
Date of Submission: Jan 01, 2017
Date of Peer Review: Mar 08, 2017
Date of Acceptance: Apr 06, 2017
Date of Publishing: Jul 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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