Correlation of Vitamin D3 Levels and SCORAD Index in Atopic Dermatits: A Case Control StudyCorrespondence Address :
Dr. Tejinder Kaur,
Associate Professor, Department of Dermatology, Venereology and Leprosy, Govt. Medical College, Amritsar, Punjab, India.
Introduction: Atopic Dermatitis (AD) is a common chronic inflammatory condition characterized clinically by pruritus and eczematous lesions. An inverse relationship has been suggested between serum 25-hydroxyvitamin D concentration and severity of atopic dermatitis.
Aim: We carried out this controlled cross sectional study to evaluate the association between the serum vitamin D3 levels and SCORAD index.
Materials and Methods: For this study, 40 patients with clinical diagnosis of AD based on UK diagnostic criteria were enrolled and forty patients with minor ailments like superficial bacterial, fungal or viral infections and not suffering from atopic dermatitis were taken as controls. Salient presentations were recorded in a pre-set proforma. Serum 25-hydroxyvitamin D levels were determined through Sandwich-ELISA technique. SCORAD (Scoring AD) index was used to evaluate the severity of the disease.
Results: Mean value of serum 25-hydroxyvitamin D levels in cases was 30.38nmol/l whereas in controls, it was 53.46 nmol/l. The decrease in serum levels in cases was statistically highly significant (p-value <0.001). Mean±S.D of serum vitamin D levels in mild disease was 33.29±5.89 nmol/l, in moderate disease was 31.52±6.04 nmol/l and in severe form of disease was 21.24±3.17nmol/l. The correlation between SCORAD and serum 25-hydroxyvitamin D levels was also statistically significant.
Conclusion: The data suggests an inverse relationship between serum levels of vitamin D3 and the SCORAD Index.
Atopic dermatitis, SCORAD index, Vitamin D3
Saurabh Sharma, Tejinder Kaur, Suresh Kumar Malhotra, Jaswant Rai, Sunil Chaudhari. CORRELATION OF VITAMIN D3 LEVELS AND SCORAD INDEX IN ATOPIC DERMATITS: A CASE CONTROL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2017 July [cited: 2017 Jul 21 ]; 11:WC01-WC03. Available from
Date of Submission: Feb 12, 2017
Date of Peer Review: Mar 22, 2017
Date of Acceptance: Apr 17, 2017
Date of Publishing: Jul 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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