Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : July | Volume : 11 | Issue : 7 | Page : ZC09 - ZC13

Comparative Evaluation of Bioactive Glass Putty and Platelet Rich Fibrin in the Treatment of Human Periodontal Intrabony Defects: A Randomized Control Trial

Akbar Naqvi, D. Gopalakrishnan, Meenu Taneja Bhasin, Nilima Sharma, Khushtar Haider, Santosh Martande

1. Lecturer, Department of Dentistry, HIMSR and HAHC Hospital, Hamdard University, New Delhi, India. 2. Professor and Head, Department of Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India. 3. Associate Professor, Department of Periodontics and Oral Implantology, Santosh Dental College, Santosh University, Ghaziabad, Uttar Pradesh, India. 4. Associate Professor, Department of Dentistry, HIMSR and HAHC Hospital, Hamdard University, New Delhi, India. 5. Demonstrator, Department of Dentistry, Jhansi Medical College, Uttar Pradesh, India. 6. Assistant Professor, Department of Dentistry, D.Y. Patil University, Pune, Maharashtra, India.

Correspondence Address :
Dr. Akbar Naqvi,
Lecturer, Department of Dentistry, HIMSR and HAHC Hospital, Hamdard University, New Delhi, India.
E-mail: naqvi.akbar31@gmail.com

Abstract

Introduction: Platelet-Rich Fibrin (PRF) and bioactive glass putty have been shown to be effective in promoting reduction in probing depth, gain in clinical attachment, and defect fill in intrabony periodontal defects. The individual role played by bioactive glass putty in combination with PRF is yet to be elucidated.

Aim: To compare the clinical effectiveness of the combination of PRF and bioactive glass putty and bioactive glass putty alone as regenerative techniques for intrabony defects in humans.

Materials and Methods: Ten pairs of intrabony defects were surgically treated with PRF and bioactive glass putty (Test group) on one side or bioactive glass putty alone (Control group) on other side. The primary outcomes of the study included changes in probing depth; attachment level and bone fill of osseous defect. The clinical parameters were recorded at baseline, 3, 6, and 9 months. Radiographic assessment was done using standardized intraoral periapical radiographs. Differences between baseline and postoperative measurements between the control and test groups were calculated using independent t-test. Comparisons were made within each group between baseline, 3 months, 6 months and 9 months using the ANOVA test followed by Bonferroni test.

Results: The mean probing depth reduction was greater in the test group (bioactive glass putty and PRF) i.e., (3.2±2.3 mm) than in the control group (bioactive glass putty alone) i.e., (3.15±1.06 mm). The mean CAL gain was also greater in the test group (4.1±1.73 mm) as compared to the control group (3.15±1.06 mm), (p-value<0.95). Furthermore significantly greater mean bone fill was found in the test group (7.1±1.37 mm) as compared to the control group (5.7 ± 1.64 mm), (p-value<0.043).

Conclusion: The results of this study showed both the groups bioactive glass putty alone (Control Group) and the combination of PRF and bioactive glass putty (Test Group) are effective in the treatment of intrabony defects. The bioactive glass putty appears to be a suitable vehicle to administer biologic substances like PRF and growth factors to induce the new bone regeneration.

Keywords

Bioactive glass, Bone defects, Bone regeneration, Periodontitis

How to cite this article :

Akbar Naqvi, D. Gopalakrishnan, Meenu Taneja Bhasin, Nilima Sharma, Khushtar Haider, Santosh Martande . COMPARATIVE EVALUATION OF BIOACTIVE GLASS PUTTY AND PLATELET RICH FIBRIN IN THE TREATMENT OF HUMAN PERIODONTAL INTRABONY DEFECTS: A RANDOMIZED CONTROL TRIAL. Journal of Clinical and Diagnostic Research [serial online] 2017 July [cited: 2017 Sep 20 ]; 11:ZC09-ZC13. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=July&volume=11&issue=7&page=ZC09-ZC13&id=10149

DOI and Others

DOI: 10.7860/JCDR/2017/23831.10149


Date of Submission: Aug 30, 2016
Date of Peer Review: Oct 22, 2016
Date of Acceptance: Mar 08, 2017
Date of Publishing: Jul 01, 2017


Financial OR OTHER COMPETING INTERESTS: None.

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