Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental StudyCorrespondence Address :
Dr. Rahele Arjmandi,
Postgraduate Student, Department of Orthodontics, School of Dentistry, Shahid Sadoughi University of Medical Sciences,
Daheye Fajr BLV, Imam Ave, Yazd, Iran.
Introduction: Methylphenidate is a psychostimulant drug, which is commonly used by children and teenagers. This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown.
Aim: The aim of this study was to evaluate the effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats.
Materials and Methods: Forty-two Wistar rats (male) were selected and divided to three groups, randomly (n=14). The control group (Group 1) received no drug, the experimental Group 2 received a constant dose of methylphenidate daily for 14 days while the experimental Group 3 received increasing doses of methylphenidate daily. To exert force, a NiTi coil spring was placed between the maxillary right first molar and the maxillary right central incisor. At the end of the study period, the amount of tooth movement was measured and then the rats were sacrificed for histological analysis of bone tissue. Differences between the experimental groups were analysed using Kruskal-wallis and Mann–Whitney U tests.
Results: No significant differences were found in the amount of orthodontic tooth movement or osteoclasts and lacunae, between the experimental groups (p>0.05). Mann–Whitney U analysis showed significant differences in the depth of resorption lacuna between Group 2 and 3 (p=0.037).
Conclusion: Methylphenidate has no significant effect on orthodontic tooth movement or histological features of bone tissue in rats.
Osteoclast, Psychostimulant drug, Ritalin
Hossein Aghili, Soghra Yassaei, Shokouh Taghipour Zahir, Rahele Arjmandi. EFFECT OF METHYLPHENIDATE ON ORTHODONTIC TOOTH MOVEMENT AND HISTOLOGICAL FEATURES OF BONE TISSUE IN RATS: AN EXPERIMENTAL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2017 July [cited: 2017 Sep 20 ]; 11:ZF01-ZF05. Available from
Date of Submission: Dec 24, 2016
Date of Peer Review: Feb 24, 2017
Date of Acceptance: Apr 21, 2017
Date of Publishing: Jul 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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