Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : BC06 - BC08

Study of Nitrosative Stress in ‘Pregnancy Induced Hypertension’

Kapila B Gaikwad, Nitin G Joshi, Sohan P Selkar

1. Assistant Professor, Department of Biochemistry, Government Medical College and Superspeciality Hospital, Nagpur, Maharashtra, India. 2. Associate Professor, Department of Biochemistry, Grant Medical College and JJ Hospital, Mumbai, Maharashtra, India. 3. Professor, Department of Musculoskeletal Sciences, Ravi Nair Physiotherapy College, Sawangi (Meghe), Wardha, Maharashtra, India.

Correspondence Address :
Dr. Kapila B Gaikwad,
Assistant Professor, Department of Biochemistry, Government Medical College and Superspeciality Hospital, Nagpur-440003,
Maharashtra, India.
E-mail: drkapila27@gmail.com

Abstract

Introduction: Hypertension is the most common medical problem encountered during pregnancy. Pregnancy Induced Hypertension (PIH) is also called a disease of maternal endothelium. Nitric-oxide being a potent vasodilator released by endothelial cells, its role has been implicated in PIH.

Aim: To study the role of reactive nitrogen species in PIH.

Materials and Methods: One hundred and twenty samples were selected for the study. Of these, 60 patients had PIH (case) and the rest without PIH (control). Estimation of serum nitricoxide, serum nitrothiol, serum total thiol was done.

Results: The study showed decreased NOx (Mono nitrogen oxide No and No2) levels in PIH as compared to control (p< 0.001). PIH patients had significantly higher levels of S-nitrothiols than control (p<0.01). Thiol levels were decreased in PIH as compared to control (p<0.001)

Conclusion: Thus, it is concluded from this study that nitrosative stress represents a point of convergence for several contributing factors potentially leading to the clinical manifestations of pregnancy induced hypertension. The antioxidants are used up while scavenging the free radicals.

Keywords

Free radical, Nitric oxide, Nitrothiol, Thiol

How to cite this article :

Kapila B Gaikwad, Nitin G Joshi, Sohan P Selkar. STUDY OF NITROSATIVE STRESS IN ‘PREGNANCY INDUCED HYPERTENSION’. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 May 30 ]; 11:BC06-BC08. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=March&volume=11&issue=3&page=BC06-BC08&id=9396

DOI and Others

DOI: 10.7860/JCDR/2017/23960.9396

Date of Submission: Sep 05, 2016
Date of Peer Review: Oct 12, 2016
Date of Acceptance: Dec 04, 2016
Date of Publishing: Mar 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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