Effect of Sodium Valproate and Docosahexaenoic Acid on Pain in RatsCorrespondence Address :
Dr. Laxminarayana Kurady Bairy,
Professor, Department of Pharmacology, Kasturba Medical College, Manipal-576104, Karnataka, India.
Introduction: Analgesics are commonly prescribed medications used to alleviate pain of various aetiologies without affecting the patient’s consciousness. They interfere with the transmission of pain signals. A commonly used antiepileptic drug, sodium valproate has been used in various non-epileptic conditions like migraine prophylaxis and in the treatment of bipolar disorder because of the multiple mechanisms by which it acts. Docosahexanoic Acid (DHA), an omega 3 fatty acid, is known to possess analgesic activity. We planned a study to assess the effect of sodium valproate alone and in combination with DHA in rat models of pain.
Aim: To evaluate the analgesic activity of sodium valproate and DHA supplementation using various experimental models in albino Wistar rats.
Materials and Methods: For analgesic activity, A total of 48 adult Wistar albino rats were divided into eight groups of six rats each. Group I was control (distil water 1 ml/kg), Group II received intraperitoneal injection of tramadol (10 mg/kg), Group III, IV, V were injected intraperitoneal sodium valproate 100, 200, 400 mg/kg with distil water respectively and Group VI, VII, VIII were given sodium valproate 100, 200, 400 mg/kg plus DHA 300 mg/kg (intraperitoneal) respectively. Analgesic activity was assessed using hot plate, tail flick and acetic acid writhing models.
Results: We found that sodium valproate at higher doses (400 mg/kg) used either alone along with DHA (300 mg/kg) showed statistically significant analgesic activity in comparison to control in various experimental models for assessing pain.
Conclusion: Combination of sodium valproate along with DHA has shown promising analgesic activity.
Analgesia, Antiepileptic, Acetic acid Writhing, Hot plate, Tail flick
Sushil Kiran Kunder, Laxminarayana Kurady Bairy, Avinash Arivazhahan. EFFECT OF SODIUM VALPROATE
ACID ON PAIN IN RATS. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Apr 28 ]; 11:FF05-FF08. Available from
Date of Submission: Oct 25, 2016
Date of Peer Review: Dec 16, 2016
Date of Acceptance: Jan 26, 2017
Date of Publishing: Mar 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
- PubMed Central® (PMC)New
- Academic Search Complete Database
- Chemical Abstracts Service
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Open J-Gate
- Popline (reproductive health literature)