Early Experience of Sofosbuvir based Combination Therapy in “Real-Life” Cohort with Chronic Hepatitis-C InfectionCorrespondence Address :
Dr. Rajiv Mehta,
Consultant Gastroenterologist, Department of Gastroenterology, Surat Institute of Digestive Sciences (SIDS),
Surat-395002, Gujarat, India.
Introduction: There is scarcity of data in literature regarding the treatment response with Sofosbuvir (SOF) based therapy in Indian patients with chronic Hepatitis-C Virus (HCV) infection.
Aim: This study was designed to observe initial treatment response to SOF based therapy in a “real-life” cohort of Indian patients with HCV infection.
Materials and Methods: This is a prospective, observational and single center study. A total of 107 patients who were diagnosed with chronic HCV infection and received SOF based treatment between March 2015 and December 2015 were included. The patients were treated with either triple drug regimen [SOF, Ribavirin (RBV) and Pegylated Interferon-a (Peg IFN-a)] or dual drug regimen (SOF and RBV) for either 12 or 24 weeks. The virological responses were obtained at baseline and thereafter weekly (up to four weeks) till viral load became undetected during treatment.
Results: A total of 107 patients who received SOF based therapy for chronic HCV infection were included in the study. Mean age of the patients was 48.7±10.7 years. Among included patients, 24 (22.4%) patients were treatment-experienced. Majority of the patients (n=69; 64.5%) were infected with HCV genotype-3. Except one patient, all the included patients achieved virological response up to week-4 of the treatment. There was statistically insignificant association between virological response (up to four week of the treatment) and severity of the disease (cirrhosis and non-cirrhosis) or treatment status (treatment-naïve and treatment-experienced), or HCV genotype (genotype-1 and 3).
Conclusion: The results of this observational study demonstrated rapid initial virological response of SOF based therapy in “real-life” cohort of Indian patients with chronic HCV infection. However, long-term follow-up data are needed to ensure the sustained antiviral efficacy of SOF based therapy.
Direct acting antivirals, Genotype-1, Genotype-3, Pegylated interferon, Ribavirin
Rajiv Mehta, Mayank Kabrawala, Subhash Nandwani, Rini Tekriwal, Payal Nandania. EARLY EXPERIENCE OF SOFOSBUVIR BASED COMBINATION THERAPY IN “REAL-LIFE” COHORT WITH CHRONIC HEPATITIS-C INFECTION. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Apr 28 ]; 11:OC05-OC08. Available from
Date of Submission: Jul 30, 2016
Date of Peer Review: Sep 27, 2016
Date of Acceptance: Oct 21, 2016
Date of Publishing: Mar 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
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