Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : OC13 - OC16

Role of Omega-3 Fatty Acids on Lipid Profile in Diabetic Dyslipidaemia: Single Blind, Randomised Clinical Trial

Shaylika Chauhan, Hanish Kodali, Jawad Noor, Karuna Ramteke, Vidisha Gawai

1. Resident Physician, Department of Internal Medicine, Saint Peter’s University Hospital, New Brunswick, New Jersey, USA. 2. Epidemiology-Biostatistics, MPH, City University of New York, New York, USA. 3. Research Associate, Department of Pulmonology, New York Methodist Hospital, New York, USA. 4. Medical Advisor Gufic Biosciences, Department of Pharmacology, Government Medical College, Miraj, Maharashtra, India. 5. Medical Officer, Department of Pharmacology, Government Medical College, Miraj, Maharashtra, India.

Correspondence Address :
Dr. Shaylika Chauhan,
Resident Physician, Department of Internal Medicine, Saint Peter’s University Hospital, New Brunswick, New Jersey, USA.
E-mail: schauhan@saintpetersuh.com

Abstract

Introduction: Diabetic dyslipidaemia is characterised by hypertriglyceridaemia, low High Density Lipoprotein (HDL), postprandial lipimea, small and dense LDL particles is considered to be a major predisposing factor for various macrovascular complications. Omega-3 fatty acids are fish oil derivative introduced in the market for dyslipidaemia associated with increased triglyceride level.

Aim: To study the effect of omega-3 fatty acids on lipid profile in Type II diabetes patients.

Materials and Methods: This study was prospective, single blind, randomized comparative trial. Hundred patients were randomized into three groups. Group I received metformin 500 mg twice daily and placebo, Group II received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) once daily and the Group III received metformin 500 mg twice daily and omega-3 fatty acids (1 gram) twice daily. ANOVA test was applied for analysis.

Results: Group II was effective in reducing the triglyceride level from 144.59±14.18 mg/dl to 101±13.31 mg/dl which was significant as compared to Group I from 147.67±18.57 mg/dl to 145.8±19.86 mg/dl respectively. Group III containing 1 g of omega-3 fatty acids twice daily showed decrease from 144.83±22.17 mg/dl to 86±17.46 mg/dl and was more effective in reducing triglyceride levels than Group II containing 1 gram of omega-3 fatty acids once daily.

Conclusion: Omega-3 fatty acids can be given in conjunction with metformin to reduce triglyceride levels in diabetic dyslipidaemia without any adverse drug reactions or any drug interaction. Omega-3 fatty acids were effective in reducing the triglyceride level significantly as compared to placebo. Two grams of omega-3 fatty acids were more effective than 1 gram of omega-3 fatty acids in reducing triglyceride levels.

Keywords

Hypertriglyceridaemia, Postprandial lipimea, Triglyceride

How to cite this article :

Shaylika Chauhan, Hanish Kodali, Jawad Noor, Karuna Ramteke, Vidisha Gawai. ROLE OF OMEGA-3 FATTY ACIDS ON LIPID PROFILE IN DIABETIC DYSLIPIDAEMIA: SINGLE BLIND, RANDOMISED CLINICAL TRIAL. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Mar 24 ]; 11:OC13-OC16. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=March&volume=11&issue=3&page=OC13-OC16&id=9449

DOI and Others

DOI: 10.7860/JCDR/2017/20628.9449

Date of Submission: Apr 09, 2016
Date of Peer Review: Jun 01, 2016
Date of Acceptance: Oct 01, 2016
Date of Publishing: Mar 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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