Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : OC21 - OC24

An Assessment of Osteoporotic Conditions among Users and Non-Users of Warfarin: A Case-Control Study

Aseel Hadi Abdulameer, Syed Azhar Bin Syed Sulaiman, Muhamad Bin Sk Abdul Kader

1. Postgraduate Student, Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia. 2. Professor, Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia. 3. Faculty, Department of Cardiology, Hospital Pulau Pinang, Malaysia.

Correspondence Address :
Mrs. Aseel Hadi Abdulameer,
Postgraduate Student, Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia,
Penang-11800, Malaysia.
E-mail: ahmed2010y66@yahoo.com

Abstract

Introduction: Warfarin is an oral anticoagulant which is associated with a decrease in Bone Mass Density (BMD).

Aim: The study aimed to explore the prevalence of osteoporosis conditions in Malaysians with chronic warfarin patients using calcaneal quarter of Quantitative Ultrasound (QUS) machine and to investigate whether long-term sodium warfarin therapy that antagonizes vitamin K is affecting the increasing rate of osteoporosis in Penang and to find the risk factors of getting osteoporosis among warfarin users and its non users.

Materials and Methods: A case-control study was conducted among 130 patients using warfarin, attending the outpatient clinic at Hospital Pulau Pinang. A convenience sampling method was used to recruit the required sample. Another 140 subjects were selected from the community as a control group (non-users of warfarin).

Results: This study showed that more than three-quarter patients (82%) were at high risk of abnormal BMD. The warfarin users were two times more likely to have a higher osteoporosis risk compared to control group. Moreover, BMD has a negative correlation with age, but has a positive correlation with Body Mass Index (BMI). Patients showed a negative correlation with a higher dose of warfarin intake.

Conclusion: This study concluded that osteopenia and osteoporosis are serious problems between users and non-users warfarin in Penang. Therefore, it should be taken into consideration in the Malaysian Health Ministry’s agenda.

Keywords

Anticoagulant drugs, Bone mineral density, Osteoporosis, Vitamin K

How to cite this article :

Aseel Hadi Abdulameer, Syed Azhar Bin Syed Sulaiman, Muhamad Bin Sk Abdul Kader. AN ASSESSMENT OF OSTEOPOROTIC CONDITIONS AMONG USERS AND NON-USERS OF WARFARIN: A CASE-CONTROL STUDY. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Apr 25 ]; 11:OC21-OC24. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=March&volume=11&issue=3&page=OC21-OC24&id=9483

DOI and Others

DOI: 10.7860/JCDR/2017/23829.9483

Date of Submission: Aug 30, 2016
Date of Peer Review: Sep 23, 2016
Date of Acceptance: Oct 15, 2016
Date of Publishing: Mar 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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