Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : QC35 - QC38

A Comparison of 2-Methoxyestradiol Value in Women with Severe Preeclampsia Versus Normotensive Pregnancy

John Wantania, Ahsanuddin Attamimi, Rukmono Siswishanto

1. Associate Professor, Department of Obstetric and Gynaecology, Maternal Foetal Medicine Division, Medical Faculty, Sam Ratulangi University, Manado, Indonesia. 2. Assistant Professor, Department of Obstetric and Gynaecology, Maternal Foetal Medicine Division, Medical Faculty, Gadjah Mada University, Yogyakarta, Indonesia. 3. Associate Professor, Department of Obstetric and Gynaecology, Maternal Foetal Medicine Division, Medical Faculty, Gadjah Mada University, Yogyakarta, Indonesia.

Correspondence Address :
Dr. John Wantania,
Department of Obstetric and Gynaecology, Sam Ratulangi University, Prof R.D. Kandou General Hospital,
Jalan Raya Tanawangko No 56, Manado, North Sulawesi, Indonesia.
E-mail: john_w_og@yahoo.com

Abstract

Introduction: Preeclampsia is a pregnancy complication characterized by high blood pressure and proteinuria. Endothelial dysfunction is a major theory suggested as its aetiology. It is caused by antiangiogenic condition characterized by low Vascular Endothelial Growth Factor (VEGF). An estradiol metabolite, called 2-Methoxy Estradiol (2-ME), is produced with the help of Catechol-O-Methyltransferase (COMT). This substance has an important role in VEGF expression. A 2-ME is suppressed in women with preeclampsia.

Aim: To compare 2-ME in women with severe preeclampsia and normotensive pregnancy.

Materials and Methods: A total of 80 subjects qualified the inclusion and exclusion criteria, were divided into two groups (40 each): the severe preeclampsia and the normotensive pregnancy. Blood sample was collected and examined with the ELISA 2-ME kit (Cayman). The data were compared and calculated using Fisher-Exact test to examine 2-ME differences between the two groups.

Results: Women age, parity, and gestational age showed a non significant difference between both groups. Nonetheless, the BMI before pregnancy and the history of preeclampsia in the past pregnancy showed significant differences. In this study, the 2-ME value was lower in the severe preeclampsia group compared to the normotensive.

Conclusion: This study concludes that 2-ME value in severe preeclampsia is lower than normotensive pregnancy. A lower 2-ME value may indicate COMT not producing enough 2-ME which in turn may cause the pre-eclampsia.

Keywords

Body mass index, Estradiol metabolite, Preeclampsia

How to cite this article :

John Wantania, Ahsanuddin Attamimi, Rukmono Siswishanto. A COMPARISON OF 2-METHOXYESTRADIOL VALUE IN WOMEN WITH SEVERE PREECLAMPSIA VERSUS NORMOTENSIVE PREGNANCY. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Apr 28 ]; 11:QC35-QC38. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=March&volume=11&issue=3&page=QC35-QC38&id=9603

DOI and Others

DOI: 10.7860/JCDR/2017/21516.9603


Date of Submission: May 19, 2016
Date of Peer Review: Jun 09, 2016
Date of Acceptance: Nov 14, 2016
Date of Publishing: Mar 01, 2017


Financial OR OTHER COMPETING INTERESTS: None.

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