Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : SC05 - SC06

Study on Steroid Induced Ocular Findings in Children with Nephrotic Syndrome

Vijay Agrawal, Kusum Devpura, Laxmikant Mishra, Sajan Agarwal

1. Assistant Professor, Department of Paediatric, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India. 2. Professor, Department of paediatric, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India. 3. Senior Resident, Department of paediatric, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India. 4. Senior Resident, Department of Paediatric, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India.

Correspondence Address :
Dr. Vijay Agrawal,
Assistant Professor, Department of Paediatric, JK Lon Hospital, Sms Medical College, Jaipur-302004, Rajasthan, India.
E-mail: vijayagrawal30111974@gmail.com

Abstract

Introduction: Long term use of corticosteroids in Nephrotic Syndrome (NS) is associated with ocular complications such as Posterior Subcapsular Cataract (PSC), glaucoma, increased intra-ocular pressure, ptosis, mydriasis, eyelid skin atrophy, keratisis, thinning of cornea and sclera, repeated hordeolum exacerbations.

Aim: To determine ocular abnormalities in children with NS and their association with steroid dosing and duration.

Materials and Methods: Hundred patients with NS in the age group of 2-18 years, with no evidence of other systemic disease, were considered for the study. Group I included cases (66) who took standard steroid regimen for first episode of NS. Group II included cases (34) who took steroid irrationally (daily basis for long time) other than standard regimen. Steroid induced ocular complications were compared in both groups after detailed ophthalmological examination. Statistical analysis was done using Statistical Package for Social Science (SPSS-20.0).

Results: Ocular abnormalities were found in 12 patients out of 66 in Group I (18%) and 16 patients out of 34 patients in Group II (47%). Out of 12 patients of Group I who had ocular problems, three had myopic astigmatism, eight patients had PSC and one had temporal disc pallor. While in Group II, out of 16 patients who had ocular complications, two patients had raised intra ocular pressure and two patients had myopic astigmatism and 12 patients had posterior sub capsular cataract. The difference in mean cumulative steroid doses in both groups was statistically significant but no such difference was there between duration of steroid intake in both group.

Conclusion: Our study concluded that ocular complications were more common in patients with irrationally steroid intake and cumulative steroid dose intake was also significantly higher in same patients.

Keywords

Corticosteroid, Idiopathic nephrotic syndrome, Ocular complications

How to cite this article :

Vijay Agrawal, Kusum Devpura, Laxmikant Mishra, Sajan Agarwal. STUDY ON STEROID INDUCED OCULAR FINDINGS IN CHILDREN WITH NEPHROTIC SYNDROME. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Mar 26 ]; 11:SC05-SC06. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=March&volume=11&issue=3&page=SC05-SC06&id=9334

DOI and Others

DOI: 10.7860/JCDR/2017/24694.9334

Date of Submission: Oct 08, 2016
Date of Peer Review: Nov 01, 2016
Date of Acceptance: Dec 06, 2016
Date of Publishing: Mar 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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