Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : March | Volume : 11 | Issue : 3 | Page : ZC46 - ZC50

A Randomized Placebo- Controlled Double Blind Clinical Trial of Quercetin in the Prevention and Treatment of Chemotherapy-Induced Oral Mucositis

Mohammad Mahdi Kooshyar, Pegah Mosannen Mozafari, Maryam Amirchaghmaghi, Atessa Pakfetrat, Parisa Karoos, Mahdokht Rashed Mohasel, Hosein Orafai, Amir Abbas Azarian

1. Associate Professor, Department of Hematology and Oncology, Imam Reza Hospital, Mashhad University of Medicals, Mashhad, Khorasan Razavi, Iran. 2. Associate Professor, Department of Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran. 3. Associate Professor, Department of Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran. 4. Professor, Department of Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran. 5. General Dentist, Hojjati Dentistry Clinic, Mashhad, Khorasan Razavi, Iran. 6. Oral and Maxillofacial Medicine Specialist, Department of Pedodontics and Oral Medicine, North Khorasan University of Medical Sciences, Mashhad, Iran. 7. Professor, Department of Industrial Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Khorasan Razavi, I

Correspondence Address :
Dr. Pegah Mosannen Mozafari,
Vakilabad boulevard-Mashhad Dental School, Mashhad, Khorasan, Razavi, Iran.
E-mail: mosannenp@mums.ac.ir

Abstract

Introduction: Oral Mucositis (OM) is a serious complication of chemotherapy that results in painful debilitating inflammation that sometimes ends in interruption of treatment.

Aim: The study evaluated the effect of quercetin (a natural flavonoid) on preventing and treating chemotherapy induced OM in patients with blood malignancies.

Materials and Methods: This double-blind, placebo controlled randomized trial was carried out on 20 adult patients who underwent high dose chemotherapy for blood malignancies. Patients were divided into two groups (10 patients in the intervention group and 10 patients in the control group). Patients in the intervention group were administered 250 mg quercetin capsules twice daily for four weeks.

Results: Nine out of 20 patients developed OM (three in the intervention group and six in the control group). The incidence of OM was lower in the intervention group although it was not statistically significant (p=0.189). The mean severity of OM was higher in the intervention group (2.6 vs 2). Healing time, age, gender, type of malignancy, drug type and duration of OM were not different in two groups.

Conclusion: The incidence of mucositis was lower in the quercetin group, but mucositis was more severe in the intervention group, which may be due to lower oral health status in the intervention group.

Keywords

Cancer, Flavonoids, Haematologic malignancies

How to cite this article :

Mohammad Mahdi Kooshyar, Pegah Mosannen Mozafari, Maryam Amirchaghmaghi, Atessa Pakfetrat, Parisa Karoos, Mahdokht Rashed Mohasel, et al.. A RANDOMIZED PLACEBO- CONTROLLED DOUBLE BLIND CLINICAL TRIAL OF QUERCETIN IN THE PREVENTION AND TREATMENT OF CHEMOTHERAPY-INDUCED ORAL MUCOSITIS. Journal of Clinical and Diagnostic Research [serial online] 2017 March [cited: 2017 Apr 27 ]; 11:ZC46-ZC50. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=March&volume=11&issue=3&page=ZC46-ZC50&id=9571

DOI and Others

DOI: 10.7860/JCDR/2017/23975.9571



Date of Submission: Sep 06, 2016
Date of Peer Review: Oct 10, 2016
Date of Acceptance: Dec 04, 2016
Date of Publishing: Mar 01, 2017


Financial OR OTHER COMPETING INTERESTS: None.

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