Pure Primary Extragonadal Retroperitoneal Yolk Sac Tumour in a Young Child: A Case ReportCorrespondence Address :
Dr. Vineeth G Nair,
Room no.412, "A" Block, Gardyenia PG Hostel Yenepoya University Campus,
Deralakatte, Mangalore-575022, Karnataka, India.
Germ Cell Tumours (GCTs) in children are uncommon, constituting approximately only 3% of all malignancies in children younger than 15 years of age. Primary extragonadal GCTs constitute only 1-5% of all germ cell tumours and a retroperitoneal site is seen only in 4% of all extragonadal GCTs. Extragonadal GCTs arise from local transformation of primordial germ cells which have been misplaced during the migration of these cells through the midline dorsal mesentery in the fourth-sixth week of embryogenesis. GCTs in children show remarkable variability in age, site, presentation and histology. This is the case of a three-year-old male child who presented with a history of an abdominal swelling which was rapidly progressive in nature. Radiology showed a large retroperitoneal mass and lesions in the liver. Histopathology, immunohistochemistry and serum Alpha-fetoprotein (AFP) values confirmed a diagnosis of pure primary extragonadal yolk sac tumour.
Alpha- fetoprotein, Germ cell tumours, Schiller–Duval bodies
Vineeth G Nair, H S Kiran, Shanthala P R
. PURE PRIMARY EXTRAGONADAL RETROPERITONEAL YOLK SAC TUMOUR IN A YOUNG CHILD: A CASE REPORT. Journal of Clinical and Diagnostic Research [serial online] 2017 May [cited: 2017 May 25 ]; 11:ED09-ED11. Available from
Date of Submission: Oct 18, 2016
Date of Peer Review: Nov 03, 2016
Date of Acceptance: Dec 11, 2016
Date of Publishing: May 01, 2017
Financial OR OTHER COMPETING INTERESTS: None.
- PubMed Central® (PMC)New
- Academic Search Complete Database
- Chemical Abstracts Service
- Directory of Open Access Journals (DOAJ)
- Embase & EMbiology
- Google Scholar
- HINARI Access to Research in Health Programme
- Indian Science Abstracts (ISA)
- Journal seek Database
- Open J-Gate
- Popline (reproductive health literature)