Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : May | Volume : 11 | Issue : 5 | Page : FC01 - FC05

A Comparative Study on Clinical and Biochemical Parameters in Amlodipine and Cilnidipine Treated Hypertensive Patients

Kiran Shetty, Ranjan Shetty, Lakshminarayana Bairy, Pragna Rao, Amruth Kiran, Manjunath Shetty, Deepak, Vidya Nayak

1. Research Scholar, Department of Cardiology, KMC, Manipal University Manipal, Karnataka, India. 2. Professor, Department of Cardiology, KMC, Manipal University, Manipal, Karnataka, India. 3. Professor, Department of Pharmacology, KMC, Manipal University, Manipal, Karnataka, India. 4. Professor, Department of Pharmacology, KMC, Manipal University, Manipal, Karnataka, India. 5. Lecturer, Department of Pharmacology, MMMC, Manipal University, Manipal, Karnataka, India. 6. Lecturer, Department of Pharmacology, MMMC, Manipal University, Manipal, Karnataka, India. 7. Research Scholar, Department of Cardiology, KMC, Manipal University, Manipal, Karnataka, India. 8. Assistant Professor, Department of Cardiovascular Technology, SOHAS, Manipal University, Manipal, Karnataka, India.

Correspondence Address :
Dr. Ranjan Shetty,
Professor, Department of Cardiology, KMC, Manipal University, Manipal-576104, Karnataka, India.
E-mail: ranjanshettyk@yahoo.com

Abstract

Introduction: Hypertension is a major health issue worldwide. Calcium Channel Blockers (CCBs) are the most commonly used antihypertensive agents. CCBs act on voltage-dependent calcium channels and they were categorized into two subclasses, Dihydropyridine (DHP) and non-Dihydropyridine (non-DHP) derivative. Amlodipine is a third generation L-type of DHP and cilnidipine is a novel L/N-type of DHP CCB, both drugs have excellent pharmacological profiles with the unique actions.

Aim: To study the clinical and biochemical profile in amlodipine and cilnidipine treated mild to moderate hypertensive patients.

Materials and Methods: The present study was a cross-sectional study. A total of 140 mild to moderate hypertensive patients (HTN classified according to Joint National Committee-8 (JNC-8) HTN guideline), 70 were in Amlodipine group (Group-A), and other 70 patients were in Cilnidipine group (Group- B). Group-A receiving Tab Amlodac 5 mg/day and Group-B receiving Tab Cilacar 10 mg/day, and both the group receiving respective medications more than six months. Patients enrolled into the study with due consideration of eligibility criteria. Demographic, clinical and biochemical parameters were noted and compared.

Results: Demographic parameters are matched, there was no significant difference seen between two study groups. Systolic and Diastolic Blood Pressure (SBP and DBP) showed a significant difference (p<0.001). There was no significant difference in pulse rate between the two groups, both QT/QTc showed statistically significant difference (p<0.001). The biochemical parameters like serum creatinine, albumin, globulin, total protein, serum Na+, fractional excretion of Na+, serum osmolality, vanillyl mandelic acid, were compared between two study groups, there was no significant difference seen between the two groups.

Conclusion: The amlodipine and cilnidipine both are equally effective antihypertensive drugs. Cilnidipine treated group showed more reduction in blood pressure than the amlodipine treated group and there was no significant change in heart rate between the two groups. Cilnidipine group showed comparatively shortened QT/QTc interval than the amlodipine group.

Keywords

Calcium channel blocker, Catecholamine, QT interval, Vanillyl mandelic acid

How to cite this article :

Kiran Shetty, Ranjan Shetty, Lakshminarayana Bairy, Pragna Rao, Amruth Kiran, Manjunath Shetty, et al.. A COMPARATIVE STUDY ON CLINICAL AND BIOCHEMICAL PARAMETERS IN AMLODIPINE AND CILNIDIPINE TREATED HYPERTENSIVE PATIENTS. Journal of Clinical and Diagnostic Research [serial online] 2017 May [cited: 2017 May 24 ]; 11:FC01-FC05. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=May&volume=11&issue=5&page=FC01-FC05&id=9763

DOI and Others

DOI: 10.7860/JCDR/2017/23825.9763


Date of Submission: Aug 30, 2016
Date of Peer Review: Oct 08, 2016
Date of Acceptance: Nov 28, 2016
Date of Publishing: May 01, 2017


Financial OR OTHER COMPETING INTERESTS: None.

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