Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : November | Volume : 11 | Issue : 11 | Page : NC01 - NC05

Dietary Omega-3 Fatty Acids Supplements for Dry Eye in Psoriasis: Are they Effective?

Rahul Bhargava, Mukesh Rajpoot, Yogesh Arora, Shiv K Sharma, Shalini Sharma

1. Professor, Department of Ophthalmology, SMSR, Sharda University, Greater Noida, Uttar Pradesh, India. 2. Senior Resident, Department of Ophthalmology, SMSR, Sharda University, Greater Noida, Uttar Pradesh, India. 3. Professor, Department of Ophthalmology, SMSR, Sharda University, Greater Noida, Uttar Pradesh, India. 4. Director, Department of Ophthalmology, Rotary Eye Hospital, Palampur, Himachal Pradesh, India. 5. Senior Resident, Department of Dermatology, Rotary Eye Foundation, Palampur, Himachal Pradesh, India.

Correspondence Address :
Dr. Rahul Bhargava,
SMSR Sharda University, Greater Noida, Uttar Pradesh-201306, India.
E-mail: rahul.bhargava@sharda.ac.in

Abstract

Introduction: Dietary consumption of omega-3 fatty acids has been found to be beneficial in patients with dry eye syndrome.

Aim: To evaluate the efficacy of dietary omega-3fatty acids (O3FAs) for dry eye in patients with psoriasis with and without meibomian gland dysfunction.

Materials and Methods: An interventional, non-randomized, controlled, multi-center study was done. Psoriatic patients were recruited when they had either dry eye symptoms and/or Schirmer <6mm or Tear Film Breakup Time (TBUT) <10s. Based on the presence of Meibomian Gland Dysfunction (MGD), subjects were allocated to MGD and Non-MGD groups, respectively (n=50 each). Age and sex matched subjects with psoriasis with no ophthalmological complaints served as controls (n=50). Subjects as well as controls were dosed with two O3FAs capsules, each containing 180 mg of Eicosapentaenoic Acid (EPA) and 120mg Docosahexaenoic acid (DHA), twice daily for 3 months (720 mg of EPA +480 mg DHA/day). Evaluation was done at baseline, one, two, and three months. Change in subjective symptoms was the primary outcome measure. Change in meibomian gland score (in MGD group), Schirmer score, and Tear Film Breakup Time (TBUT) were the secondary outcome measures.

Results: Repeated-measures ANOVA revealed that there was a significant (p<0.001) change in symptoms, TBUT and Schirmer score in MGD (5, 4.6 & 4.6) and non-MGD (5.3, 1 & 5.2) groups at three months, respectively. Post-hoc test revealed that test parameters changed significantly at all points of time in MGD group. In non-MGD group the change was significant only after three months of intervention. These parameters did not change significantly in the control group at three months.

Conclusion: Dietary O3FA supplementation for three months improved dry eye symptoms, tear film stability, tear production in psoriasis patients with and without meibomian gland dysfunction.

Keywords

Dry eye scoring system, Meibomian gland dysfunction, Tear film break up time, Schirmer test

How to cite this article :

Rahul Bhargava, Mukesh Rajpoot, Yogesh Arora, Shiv K Sharma, Shalini Sharma. DIETARY OMEGA-3 FATTY ACIDS SUPPLEMENTS FOR DRY EYE IN PSORIASIS: ARE THEY EFFECTIVE?. Journal of Clinical and Diagnostic Research [serial online] 2017 November [cited: 2017 Nov 19 ]; 11:NC01-NC05. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=November&volume=11&issue=11&page=NC01-NC05&id=10799

DOI and Others

DOI: 10.7860/JCDR/2017/27490.10799

Date of Submission: Feb 13, 2017
Date of Peer Review: Mar 23, 2017
Date of Acceptance: Sep 11, 2017
Date of Publishing: Nov 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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