Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 27543

Original article / research
Year : 2017 | Month : October | Volume : 11 | Issue : 10 | Page : QC01 - QC03

Hypovitaminosis D is Associated with Gestational Diabetes Mellitus

Arijit Debnath, Mamta Gupta, Sanjay Jain, SupriyaKumari, Tamoghna Biswas, Somosri Ray, Santosh Kumar Gupta

1. Clinical Tutor, Department of Obstetrics and Gynaecology, College of Medicine and JNM Hospital, Kolkata, West Bengal, India. 2. Senior Consultant and Head, Department of Obstetrics and Gynaecology, Hindu Rao Hospital and associated NDMC Medical College, Delhi, India. 3. Senior Specialist, Department of Microbiology, Hindu Rao Hospital and Associated NDMC Medical College, Delhi, India. 4. DNB trainee, Department of Obstetrics and Gynaecology, Hindu Rao Hospital and associated NDMC Medical College, Delhi, India. 5. MD trainee, Department of Paediatrics, Medical College, Kolkata, West Bengal, India. 6. Assistant Professor, Department of Neonatology, Medical College, Kolkata, West Bengal, India. 7. Professor, Department of Biochemistry, Maulana Azad Medical College, Delhi, India.

Correspondence Address :
Dr. Mamta Gupta,
A-18, Greenview Aptt., Sector 9, Rohini-110085, Delhi, India.
E-mail: write2mamta55@gmail.com

Abstract

Introduction: Vitamin D deficiency has been shown to cause expression of insulin gene resulting in high insulin synthesis and secretion. It also decreases insulin resistance, thus affecting abnormal glucose metabolism and diabetes.

Aim: To estimate total 25-hydroxy vitamin D levels in pregnant women and to find its association with Gestational Diabetes Mellitus (GDM).

Materials and Methods: Fifty four antenatal women were randomly enrolled at 24-28 weeks gestation after conforming to exclusion criteria. Serum vitamin D, two-hour 75 grams glucose and postprandial plasma glucose levels were estimated in all women at the time of enrollment. GDM was diagnosed with plasma glucose level >140 mg/dL (Group A). Rest of the women constituted Group B or control group. They were followed up till delivery. Vitamin D status and fetomaternal outcome was evaluated.

Results: Hypovitaminosis D was found in 93% of women. There were 38.8% women (n=21) in GDM group compared to 61.2% (n=33) in control group. Vitamin D was significantly low in Group A than B (p-value 0.004). None of the women in Group A had vitamin D levels of 10 ng/mL and above compared to 37.2% in Group B. Severe vitamin D deficient women (levels <5 ng/mL) had a risk ratio of 5.647 for developing GDM. A negative correlation was observed between vitamin D levels and plasma glucose levels.

Conclusion: Hypovitaminosis D was associated with development of GDM.

Keywords

Modifiable risk factors, Plasma glucose levels, Vitamin D deficiency

How to cite this article :

Arijit Debnath, Mamta Gupta, Sanjay Jain, SupriyaKumari, Tamoghna Biswas, Somosri Ray, et al.. HYPOVITAMINOSIS D IS ASSOCIATED WITH GESTATIONAL DIABETES MELLITUS. Journal of Clinical and Diagnostic Research [serial online] 2017 October [cited: 2017 Oct 24 ]; 11:QC01-QC03. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=October&volume=11&issue=10&page=QC01-QC03&id=10691

DOI and Others

DOI: 10.7860/JCDR/2017/27433.10691

Date of Submission: Feb 10, 2017
Date of Peer Review: Mar 22, 2017
Date of Acceptance: May 09, 2017
Date of Publishing: Oct 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

JCDR is now Monthly and more widely Indexed .
  • PubMed Central® (PMC)New
  • Academic Search Complete Database
  • Chemical Abstracts Service
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhostNew
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Open J-Gate
  • Popline (reproductive health literature)
  • SCOPUS
  • www.omnimedicalsearch.com