Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : October | Volume : 11 | Issue : 10 | Page : SC06 - SC10

Effectiveness and Safety of Heparinized Saline versus Normal Saline in Maintaining Patency of Peripheral Intravenous Locks in Neonates at a Tertiary Care Hospital

Treasa Mathews, Leelavathi D Acharya, Leslie Edward Simon Lewis, Rayapudi Udaya Bhaskar,Alsha Abdul Rahim, Vivek Bhanubhai Prajapati, Vasudev Guddattu, Maria Mathews

1. Doctor of Pharmacy, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India. 2. Associate Professor, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India. 3. Professor, Department of Paediatrics, Kasturba Medical College, Manipal University, Manipal, Karnataka, India. 4. Doctor of Pharmacy, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India. 5. Doctor of Pharmacy, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India. 6. Doctor of Pharmacy, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India. 7. Associate Professor, Department of Statistics, Manipal University, Manipal, Karnataka, India. 8. Research Scholar, Department of Statistics, Prasanna School of Public Health, Manipal University, Manipal, Karnataka, India.

Correspondence Address :
Dr. Leelavathi D Acharya,
Associate Professor, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences,
Manipal University, Manipal-576104, Karnataka, India.
E-mail: leela.da@manipal.edu

Abstract

Introduction: Heparinized saline is usually used as a regular flush solution to prevent occlusion of peripheral intravenous locks in neonates but the risks associated with the use of heparin cannot be ignored in these patients.

Aim: To assess and compare the efficacy and safety of Heparinized Saline (HS) and Normal Saline (NS) flush solution in neonates.

Materials and Methods: A prospective study was conducted for a period of 12 months using 1 unit/ml HS and NS 0.9% solution. The mean number of catheters removed due to nonelective reasons was calculated to evaluate the effectiveness of flushing solutions. To evaluate the safety, the reason for catheter removal was noted and platelet nadir was used to assess the thrombocytopenia. Poisson regression, Pearson Chi-square test and stratified analysis were conducted.

Results: Data were analysed from 100 neonates. We found no significant difference between HS and NS flushes in neonates in maintaining the patency of 24 gauge peripheral intravenous locks {rate ratio= 1.12, p-value =0.584}. Gestational age, body weight and site of insertion did not significantly affect the patency. The reasons for removal of catheter were similar in both the groups and majority were due to non-elective reasons. HS group reported more cases of thrombocytopenia that was attributed to sepsis.

Conclusion: Standard NS can be considered as an alternative flush in neonates as both the solutions were found to be equally efficacious and safe in our patient group. Factors like gestational age, body weight and site of insertion did not significantly affect the patency.

Keywords

Catheterization, Chloride, Double-blind method, Heparin, Neonatology, Newborn, Sodium therapeutic use

How to cite this article :

Treasa Mathews, Leelavathi D Acharya, Leslie Edward Simon Lewis, Rayapudi Udaya Bhaskar, Alsha Abdul Rahim, Vivek Bhanubhai Prajapati, et al.. EFFECTIVENESS AND SAFETY OF HEPARINIZED SALINE VERSUS NORMAL SALINE IN MAINTAINING PATENCY OF PERIPHERAL INTRAVENOUS LOCKS IN NEONATES AT A TERTIARY CARE HOSPITAL. Journal of Clinical and Diagnostic Research [serial online] 2017 October [cited: 2017 Nov 19 ]; 11:SC06-SC10. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=October&volume=11&issue=10&page=SC06-SC10&id=10736

DOI and Others

DOI: 10.7860/JCDR/2017/26797.10736

Date of Submission: Jan 17, 2017
Date of Peer Review: Mar 30, 2017
Date of Acceptance: Sep 04, 2017
Date of Publishing: Oct 01, 2017

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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