Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2017 | Month : September | Volume : 11 | Issue : 9 | Page : OC06 - OC09

Validity of Simplified Ankylosing Spondylitis Disease Activity Scores (SASDAS) in Indian Ankylosing Spondylitis Patients

Nagma Bansal, Lalit Duggal, Neeraj Jain

1. DNB Trainee, Department of Rheumatology, Sir Ganga Ram Hospital, New Delhi, India. 2. Consultant, Department of Rheumatology, Sir Ganga Ram Hospital, New Delhi, India. 3. Consultant, Department of Rheumatology, Sir Ganga Ram Hospital, New Delhi, India.

Correspondence Address :
Dr. Nagma Bansal,
DNB Trainee, Department of Rheumatology, Sir Ganga Ram Hospital, New Delhi, India.
E-mail: nagmabansal09@gmail.com

Abstract

Introduction: Ankylosing Spondylitis Disease Activity Score (ASDAS) is a complex score for monitoring disease activity in Ankylosing Spondylitis (AS).

Aim: To develop a simplified version of the ASDAS.

Materials and Methods: Consenting 254 AS patients (modified New York and/or Assessment in Ankylosing Spondylitis 2009 criteria) were recruited. Sociodemographic data and disease characteristics such as Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), and AS Quality of Life (ASQoL), Erythrocyte Sedimentation Rate (ESR), and C-Reactive Protein (CRP) were collected. Simplified ASDAS (SASDAS) was calculated as the simple sum of patient global assessment, back pain (BASDAI question no.2), peripheral pain and swelling (BASDAI question no.3), morning stiffness (BASDAI question no.6), and either ESR in mm/hour (for SASDAS-ESR) or CRP in mg/L (for SASDAS-CRP); this sum was divided by 10 to obtain the final score.

Results: Most patients (224/254; 88.19%) were males with the median age of 30 years. SASDAS-ESR and SASDAS-CRP showed good correlation with ASDAS-ESR and ASDAS-CRP respectively (r2=0.78 and 0.58 respectively; p-value<0.0001). SASDAS-ESR showed good correlation with CRP (r=0.50) and is fairly correlated with backpain (r=0.19), morning stiffness (r=0.21) and peripheral pain (r=0.21); SASDAS-CRP showed good correlation with BASFI (r=0.32), and ESR (r=0.55) (all p-value<0.0001). Using established ASDAS cut-off values, corresponding cut-off points between ‘inactive’, ‘moderate’, ‘high’, and ‘very high’ disease activities (with optimum sensitivity and specificity) were 1.83, 2.45 and 4.45 for SASDAS-ESR, and 0.79, 1.50, and 3.26 for SASDAS-CRP. Both the SASDAS scores showed good correlation with BASDAI.

Conclusion: SASDAS-ESR and SASDAS-CRP are reliable, easy-to-calculate scores for disease activity assessment in Asian Indian AS patients; which can be used in daily clinical practice

Keywords

C-Reactive Protein, Back pain, Erythrocyte sedimentation rate

How to cite this article :

Nagma Bansal, Lalit Duggal, Neeraj Jain. VALIDITY OF SIMPLIFIED ANKYLOSING SPONDYLITIS DISEASE ACTIVITY SCORES (SASDAS) IN INDIAN ANKYLOSING SPONDYLITIS PATIENTS. Journal of Clinical and Diagnostic Research [serial online] 2017 September [cited: 2017 Nov 22 ]; 11:OC06-OC09. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2017&month=September&volume=11&issue=9&page=OC06-OC09&id=10540

DOI and Others

DOI: 10.7860/JCDR/2017/22665.10540

Date of Submission: Jul 09, 2016
Date of Peer Review: Oct 29, 2016
Date of Acceptance: Jan 26, 2017
Date of Publishing: Sep 01, 2017

Financial OR OTHER COMPETING INTERESTS: None.

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