Association between Vascular Endothelial Markers and Carotid Intima-Media Thickness in Children and Adolescents with Type 1 Diabetes MellitusCorrespondence Address :
Dr. Noushin Rostampour,
Assistant Professor, Department of Paediatric Endocrinology, Shahrekord University of Medical Sciences,
Kashani Bld, Shahrekord, Iran-8815713471.
Introduction: Type 1 Diabetes Mellitus (T1DM) is one of the important risk factor for cardiovascular disease. Endothelial dysfunction and increased Carotid Intima-Media Thickness (CIMT) result in cardiovascular complications. Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intercellular Adhesion Molecule-1 (ICAM-1) are two adhesion molecules that are markers of early atherosclerosis and play a significant role in developing atherosclerosis.
Aim: To evaluate CIMT and its association with the levels of ICAM-1 and VCAM-1 in children and adolescents with T1DM. Materials and Methods: In this descriptive, cross-sectional study conducted between April 2013 and September 2014, 29 children aged 7-20 years with T1DM for at least two years and 29 age and sex-matched, healthy individuals were evaluated. Plasma level of ICAM-1 and VCAM-1 was measured by ELISA, and CIMT via Doppler ultrasound was also assessed. The data were analysed by t-test and Pearson’s correlation coefficient in SPSS 16.0 (p=0.05).
Results: Independent t-test indicated that there is a significant difference in ICAM-1 level between the patients and controls (p<0.001). Further, CIMT was significantly higher in diabetic subject (p<0.001). CIMT was not significantly associated with the level of VCAM-1 and ICAM-1 in the patients (p>0.5).
Conclusion: ICAM-1 and VCAM-1 were not associated with CIMT but, CIMT and level of ICAM-1 were significantly, higher in diabetic patients, and therefore could be used as useful tools for identification of early atherosclerosis in children and adolescents with T1DM.
Adhesion molecules, Atherosclerosis, Endothelial dysfunction
Noushin Rostampour, Kiavash Fekri, Elham Hashemi-Dehkordi, Mahdieh Obodiat. ASSOCIATION BETWEEN VASCULAR ENDOTHELIAL MARKERS AND CAROTID INTIMA-MEDIA THICKNESS IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS. Journal of Clinical and Diagnostic Research [serial online] 2017 September [cited: 2017 Nov 22 ]; 11:SC01-SC05. Available from
Date of Submission: Jan 07, 2017
Date of Peer Review: Mar 21, 2017
Date of Acceptance: Aug 03, 2017
Date of Publishing: Sep 01, 2017
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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