Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

Users Online : 730

Original article / research
Year : 2017 | Month : September | Volume : 11 | Issue : 9 | Page : UC01 - UC03

Therapeutic Efficacy of Ozone Injection into the Knee for the Osteoarthritis Patient along with Oral Celecoxib and Glucosamine

XU Feng, Li Beiping

1. Associate Professor, Department of Anaesthesiology, Xuzhou First People’s Hospital, Xuzhou, Jiangsu, China. 2. Chief Physician, Department of Anaesthesiology, Xuzhou First People’s Hospital, Xuzhou, Jiangsu, China.

Correspondence Address :
Dr. Xu Feng,
No.19, Zhongshanbailu Route, Quanshan district, Xuzhou, Jiangsu, China.


Introduction: Suffering from osteoarthritis is prevalent among elderly patients so the use of intra-articular injection of medical ozone may well be the effective way to relieve their pain.

Aim: To evaluate the effect of intra-articular injection of medical ozone given into the knee of the osteoarthritis patients, and to compare it with taking celecoxib and glucosamine orally.

Materials and Methods: In the present study, 76 patients suffering from osteoarthritis were randomly assigned into two groups. In the ozone group, 20 ml ozone-oxygen mixture gas concentration of 20 µg/ml was injected into knee articular cavity and each patient took oral celecoxib and glucosamine hydrochloride. Patients in control group only took the celecoxib and glucosamine hydrochloride orally. Pain score and Lysholm knee score were measured prior to the injection (pretreatment) and at one, three, six weeks after the beginning of the treatment (posttreatment).

Results: After the treatment, the pain intensity and function significantly improved in the two groups compared with the pretreatment (p<0.05). In the ozone group, three weeks after intervention, the pain score improved significantly when compared with the control group (p<0.05). After the treatment, the lysholm scores increased significantly (p<0.05), but in the ozone group, it improved faster.

Conclusion: Intra-articular injection of ozone plus oral celecoxib and glucosamine could significantly decrease pain intensity in patients with mild to moderate Knee Osteoarthritis (KOA), and improve their functional status early than oral celecoxib and glucosamine only.


Intra-articular, Medicine, Pain

How to cite this article :

XU Feng, Li Beiping. THERAPEUTIC EFFICACY OF OZONE INJECTION INTO THE KNEE FOR THE OSTEOARTHRITIS PATIENT ALONG WITH ORAL CELECOXIB AND GLUCOSAMINE. Journal of Clinical and Diagnostic Research [serial online] 2017 September [cited: 2018 Jan 16 ]; 11:UC01-UC03. Available from

DOI and Others

DOI: 10.7860/JCDR/2017/26065.10533


Date of Submission: Dec 21, 2016
Date of Peer Review: Jan 27, 2017
Date of Acceptance: Jun 26, 2017
Date of Publishing: Sep 01, 2017

JCDR is now Monthly and more widely Indexed .
  • Emerging Sources Citation Index (Web of Science, thomsonreuters)
  • Index Copernicus ICV 2016: 132.37
  • Academic Search Complete Database
  • Directory of Open Access Journals (DOAJ)
  • EBSCOhost
  • Embase & EMbiology
  • Google Scholar
  • HINARI Access to Research in Health Programme
  • Indian Science Abstracts (ISA)
  • Journal seek Database
  • Google
  • Popline (reproductive health literature)