A Case of Idiopathic CD4 Lymphocytopenia (ICL): Immunological Mystery Leading to Storm of DiseasesCorrespondence Address :
Dr. Arvind Kumar,
4097, Teaching Block, All India Institute of Medical Sciences, New Delhi-110029, India.
In medicine for any disease, common differentials should be thought first but in cases of recurrent and resistant infections where desired result is not achieved with protocol and evidence based management, other rare causes should come into our minds. In this case, after extensive academic review, we ultimately reached to a very rare diagnosis of idiopathic CD4+ deficiency. So, in cases of chronic and recurrent resistant to treat infections, besides known causes of secondary immunodeficiency, idiopathic CD4+ deficiency should also be kept in mind. While labelling it idiopathic today, it should be realised that before 1992, CD4+ deficiency associated with HIV was also thought to be idiopathic. Here we describe a case, which started as a routine case of tubercular lymphadenitis but had a rare underlying aetiology.
Cytomegalovirus, Human immunodeficiency virus, Infection, Lymphoma
Ram Manohar Talupula, Tom Jose Kakkanattu, Arvind Kumar, Ajay Gogia, Naveet Wig. A CASE OF IDIOPATHIC CD4 LYMPHOCYTOPENIA (ICL): IMMUNOLOGICAL MYSTERY LEADING TO STORM OF DISEASES. Journal of Clinical and Diagnostic Research [serial online] 2017 December [cited: 2018 Jan 18 ]; 11:OD01-OD03. Available from
Date of Submission: Apr 27, 2017
Date of Peer Review: May 24, 2017
Date of Acceptance: Oct 06, 2017
Date of Publishing: Dec 01, 2017
FINANCIAL OR OTHER COMPETING INTERESTS: None.
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