Journal of Clinical and Diagnostic Research, ISSN - 0973 - 709X

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Original article / research
Year : 2018 | Month : August | Volume : 12 | Issue : 8 | Page : EC01 - EC04

Correlation of Cytological Grading in Lymphocytic Thyroiditis with Thyroid Hormones and Antibodies - A Retrospective Study in the Era of Bethesda System of Thyroid Reporting

Supreetha Megalamane, Hemalatha Anantharamaiah, Shashidhar Nagaraj Kurpad

1. Assistant Professor, Department of Pathology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India. 2. Associate Professor, Department of Pathology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India. 3. Professor and Head, Department of Biochemistry, Sri Devaraj Urs Medical College, Kolar, Karnataka, India.

Correspondence Address :
Dr. Hemalatha Anantharamaiah,
Associate Professor, Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar-563101, Karnataka, India.
E-mail: drhemashashi@gmail.com

Abstract

Introduction: Thyroid disorders are the most common endocrine disorders affecting about 42 million people in India. Among all the disorders, Lymphocytic Thyroiditis (LT) is the second most common thyroid lesion diagnosed on cytology next to goiter.

Aim: The present study was done to grade cytological smears of LT and correlate grades with clinical presentation, Thyroid Stimulating Hormone (TSH) and antithyroid antibodies.

Materials and Methods: The present study was a retrospective study of 185 cases from June 2014 to June 2016 conducted at Sri Devaraj Urs Medical College and Research centre, Kolar, Karnataka, India. Institutional ethical clearance was obtained before the start of study. Patientís clinical and demographic details, relevant cytology smears were retrieved and graded based on Bhatia A et al., criteria. Thyroid function tests were done in 98 cases and antithyroid antibody levels values was available in 59 cases. Chi-square test and Pearsonís correlation coefficient were used and p=0.05 was considered as significant for statistical analysis.

Results: Female preponderance in the age group of 7-60 years with diffuse thyroid enlargement was the common presentation. Maximum numbers of cases were of cytological grade 2 with euthyroid and hypothyroid status. A p-value was significant for correlation of all cytological grades with TSH values. Combination of Anti Thyroid Peroxidase (ATPO) and TSH together had positive correlation with cytological grade 3.

Conclusion: Cytological grading helps in assessing the severity of the disease as it reflects the TSH levels and ATPO levels.

Keywords

Cytological grade, Thyroid antibodies, Thyroid stimulating hormone

How to cite this article :

Supreetha Megalamane, Hemalatha Anantharamaiah, Shashidhar Nagaraj Kurpad. CORRELATION OF CYTOLOGICAL GRADING IN LYMPHOCYTIC THYROIDITIS WITH THYROID HORMONES AND ANTIBODIES - A RETROSPECTIVE STUDY IN THE ERA OF BETHESDA SYSTEM OF THYROID REPORTING. Journal of Clinical and Diagnostic Research [serial online] 2018 August [cited: 2018 Jul 22 ]; 12:EC01-EC04. Available from
http://jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=August&volume=12&issue=8&page=EC01-EC04&id=11923

DOI and Others

DOI: 10.7860/JCDR/2018/35123.11923

Date of Submission: Dec 11, 2017
Date of Peer Review: Feb 26, 2018
Date of Acceptance: May 26, 2018
Date of Publishing: Aug 01, 2018

FINANCIAL OR OTHER COMPETING INTERESTS: None.

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